Minami Yoshiyuki, Ogawa Ruri, Ogura Ichiro
Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.
Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.
Pol J Radiol. 2022 Jun 8;87:e311-e315. doi: 10.5114/pjr.2022.117569. eCollection 2022.
This study was designed to investigate mandibular lesions using volumetric analysis with bone single-photon emission computed tomography/computed tomography (SPECT/CT).
Eight patients with mandibular lesions underwent SPECT/CT scan acquisition 4 hours after injection of Tc-99m hydroxymethylene diphosphonate (HMDP). Regarding volumetric analysis, maximum standar-dized uptake value (SUV) was obtained using software and a workstation (Q.Volumetrix MI and GEniE-Xeleris 4 DR, respectively). The localization and size of the volume of interest (VOI) can be drawn over the lesion, mesial, distal, and opposite side as normal using the CT, SPECT, and SPECT/CT transaxials, coronals, and sagittals as the anatomical reference. Q.Volumetrix MI can analyse SUV of lesions by organ segmentation using optional pan and zoom imaging. Then, the dosimetry software provided multiple quantitative data for a given VOI. Statistical analyses for the maximum SUV were performed by Mann-Whitney test. A -value lower than 0.05 was considered as statistically significant.
Maximum SUVs for medication-related osteonecrosis of the jaw ( = 4, 25.4 ± 4.9), chronic osteomyelitis ( = 3, 14.6 ± 3.1), and squamous cell carcinoma ( = 1, 31.7) were significantly higher than those of the opposite side as normal mandible (3.8 ± 0.7, 4.6 ± 1.8, and 7.4, respectively; = 0.000).
Volumetric analysis with SPECT/CT could be useful for the evaluation of mandibular lesions, such as detecting and surgical planning.
本研究旨在利用骨单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）的容积分析来研究下颌骨病变。
8例下颌骨病变患者在注射锝-99m亚甲基二膦酸盐（HMDP）4小时后接受SPECT/CT扫描。关于容积分析，分别使用软件和工作站（Q.Volumetrix MI和GEniE-Xeleris 4 DR）获得最大标准化摄取值（SUV）。可以使用CT、SPECT以及SPECT/CT的横轴位、冠状位和矢状位图像作为解剖学参考，在病变部位、近中、远中以及对侧正常部位绘制感兴趣区（VOI）的定位和大小。Q.Volumetrix MI可以通过使用可选的平移和缩放成像进行器官分割来分析病变的SUV。然后，剂量测定软件为给定的VOI提供多个定量数据。对最大SUV进行曼-惠特尼检验的统计分析。P值低于0.05被认为具有统计学意义。
颌骨药物性骨坏死（n = 4，25.4±4.9）、慢性骨髓炎（n = 3，14.6±3.1）和鳞状细胞癌（n = 1，31.7）的最大SUV显著高于下颌骨对侧正常部位（分别为3.8±0.7、4.6±1.8和7.4；P = 0.000）。
SPECT/CT容积分析可用于评估下颌骨病变，如检测和手术规划。
