Tezuka Yasuhito, Ogura Ichiro
Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata Niigata, Japan.
Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata Niigata, Japan.
Am J Nucl Med Mol Imaging. 2024 Aug 25;14(4):230-238. doi: 10.62347/FFPG9819. eCollection 2024.
The purpose of this study is to investigate bone SPECT/CT and diffusion-weighted MR imaging (DWI) in medication-related osteonecrosis of the jaw (MRONJ), focusing on the correlation between standardized uptake values (SUVs) and apparent diffusion coefficient (ADC) values. Twenty-nine patients with MRONJ who underwent SPECT/CT and DWI were included in this study. SUVs (maximum and mean) with SPECT/CT, and ADC values (maximum, mean and minimum) with DWI were analyzed on characteristics in MRONJ, such as stage, location, medication and underlying disease, by Mann-Whitney U test. Furthermore, the correlation between SUVs and ADC values for characteristics in MRONJ were assessed by Spearman's rank correlation test for nonparametric data. A -value lower than 0.05 was considered as statistically significant. SUVs and ADC values have no significant differences for all characteristics in MRONJ. Negative correlations were found in all cases and in stage 2 cases, and no correlations were found in stage 3 cases. In addition, negative correlations were found in maxillary cases, mandibular cases, non-bisphosphonate cases, osteoporosis cases, and malignant tumor cases. In conclusion, this study found multiple correlations between SUVs and ADC values in MRONJ, especially in stage 2. Suggesting that ADC values and SUVs may change with disease progression and the possibility of predicting MRONJ progression by SUVs and ADC values.
本研究的目的是调查骨SPECT/CT和扩散加权磁共振成像（DWI）在药物相关性颌骨坏死（MRONJ）中的应用，重点关注标准化摄取值（SUVs）与表观扩散系数（ADC）值之间的相关性。本研究纳入了29例接受SPECT/CT和DWI检查的MRONJ患者。通过Mann-Whitney U检验分析了SPECT/CT的SUVs（最大值和平均值）以及DWI的ADC值（最大值、平均值和最小值）在MRONJ中的特征，如分期、部位、用药情况和基础疾病。此外，通过Spearman秩相关检验对MRONJ特征的SUVs与ADC值之间的相关性进行非参数数据评估。P值低于0.05被认为具有统计学意义。MRONJ所有特征的SUVs和ADC值均无显著差异。在所有病例和2期病例中发现负相关，在3期病例中未发现相关性。此外，在上颌病例、下颌病例、非双膦酸盐病例、骨质疏松病例和恶性肿瘤病例中发现负相关。总之，本研究发现MRONJ中SUVs与ADC值之间存在多种相关性，尤其是在2期。提示ADC值和SUVs可能随疾病进展而变化，且存在通过SUVs和ADC值预测MRONJ进展的可能性。
