Pereira Laiz Campos, Fátima Marcelo Aguiar de, Santos Valdeene Vieira, Brandão Carolina Magalhães, Alves Izabel Almeida, Azeredo Francine Johansson
Laboratory of Pharmacokinetics and Pharmacometrics, Faculty of Pharmacy, Federal University of Bahia (UFBA), Rua Barão de Jeremoabo, 147, Salvador 40170-115, BA, Brazil.
Pharmacy Graduate Program, Federal University of Bahia, Rua Barão de Jeremoabo, 147, Salvador 40170-115, BA, Brazil.
Antibiotics (Basel). 2022 Jul 22;11(8):986. doi: 10.3390/antibiotics11080986.
Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different themes in the pharmaceutical sciences, including therapeutic drug monitoring and different stages of drug development. Although the knowledge of these disciplines is essential, they have historically been treated separately. While pharmacokinetics was limited to describing the time course of plasma concentrations after administering a drug-dose, pharmacodynamics describes the intensity of the response to these concentrations. In the last decades, the concept of pharmacokinetic/pharmacodynamic modeling (PK/PD) emerged, which seeks to establish mathematical models to describe the complete time course of the dose-response relationship. The integration of these two fields has had applications in optimizing dose regimens in treating antibacterial and antifungals. The anti-infective PK/PD models predict the relationship between different dosing regimens and their pharmacological activity. The reviewed studies show that PK/PD modeling is an essential and efficient tool for a better understanding of the pharmacological activity of antibacterial and antifungal agents.
药代动力学和药效学是药理学中与药学科学不同主题相关的领域，包括治疗药物监测和药物研发的不同阶段。虽然这些学科的知识至关重要，但从历史上看，它们一直是分开对待的。药代动力学仅限于描述给药剂量后血浆浓度的时间进程，而药效学则描述对这些浓度的反应强度。在过去几十年中，药代动力学/药效学建模（PK/PD）的概念出现了，它试图建立数学模型来描述剂量-反应关系的完整时间进程。这两个领域的整合已应用于优化抗菌和抗真菌治疗的给药方案。抗感染PK/PD模型预测不同给药方案与其药理活性之间的关系。综述研究表明，PK/PD建模是更好地理解抗菌和抗真菌药物药理活性的重要且有效的工具。
