Cegieła Urszula, Londzin Piotr, Janas Aleksandra, Pytlik Maria, Folwarczna Joanna
Department of Pharmacology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Pharmaceuticals (Basel). 2022 Jul 24;15(8):915. doi: 10.3390/ph15080915.
The gut microbiota plays an important role in maintaining homeostasis, including that of the skeletal system. Antibiotics may affect the skeletal system directly or indirectly by influencing the microbiota. Probiotic bacteria have been reported to favorably affect bones in conditions of estrogen deficiency. The aim of this study was to investigate the effects of azithromycin (AZM) administered alone or with probiotic bacteria (; LR) on bones in estrogen-deficient rats. The experiments were carried out on mature rats divided into five groups: non-ovariectomized (NOVX) control rats, ovariectomized (OVX) control rats, and OVX rats treated with: LR, AZM, or AZM with LR. The drugs were administered for 4 weeks. Serum biochemical parameters, bone mineralization, histomorphometric parameters, and mechanical properties were examined. Estrogen deficiency increased bone turnover and worsened cancellous bone microarchitecture and mechanical properties. The administration of LR or AZM slightly favorably affected some skeletal parameters of estrogen-deficient rats. The administration of AZM with LR did not lead to the addition of the effects observed for the separate treatments, indicating that the effects could be microbiota-mediated.
肠道微生物群在维持体内稳态（包括骨骼系统的稳态）中发挥着重要作用。抗生素可能通过影响微生物群直接或间接影响骨骼系统。据报道，益生菌在雌激素缺乏的情况下对骨骼有有益影响。本研究的目的是调查单独给予阿奇霉素（AZM）或与益生菌（；LR）联合使用对雌激素缺乏大鼠骨骼的影响。实验在成熟大鼠上进行，分为五组：未去卵巢（NOVX）对照大鼠、去卵巢（OVX）对照大鼠，以及用以下药物治疗的OVX大鼠：LR、AZM或AZM与LR联合使用。药物给药4周。检测血清生化参数、骨矿化、组织形态计量学参数和力学性能。雌激素缺乏会增加骨转换，使松质骨微结构和力学性能恶化。给予LR或AZM对雌激素缺乏大鼠的一些骨骼参数有轻微的有益影响。AZM与LR联合使用并未导致单独治疗时观察到的效果相加，表明这些效果可能是由微生物群介导的。
