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具有增强抗菌活性的庆大霉素固定化琼脂的合成。

Synthesis of Gentamicin-Immobilized Agar with Improved Antibacterial Activity.

作者信息

Hou Tingting, Wen Xin, Xie Lici, Gu Qixiang, Li Chengpeng

机构信息

School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.

出版信息

Polymers (Basel). 2022 Jul 22;14(15):2975. doi: 10.3390/polym14152975.

DOI:10.3390/polym14152975
PMID:35893939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9330791/
Abstract

To develop agar derivatives with good antibacterial activity and decreased gelling and melting temperatures, two agar-gentamycin conjugates with 9.20% and 12.68% gentamicin immobilized were fabricated by oxidation, Schiff base and reduction reaction, and characterized by a Fourier Transform Infrared Spectrometer, H nuclear magnetic resonance and an elemental analyzer. It was found that the modifications changed the intermolecular interactions, leading to decreased gelling and melting temperatures for the oxidized agar and slightly increased gelling and melting temperatures for agar-gentamycin conjugates. Further studies of antimicrobial properties showed that the two agar-gentamycin conjugates possessed good antibacterial activity, which was positively correlated with the dosage and the immobilization rate of gentamicin. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of agar-gentamycin conjugates with higher immobilization rates of gentamicin against were 39.1 μg/mL and 156.2 μg/mL, respectively, and the MICs and MBCs against were 19.5 μg/mL and 78.1 μg/mL, respectively. A biofilm test indicated that certain concentrations of agar-gentamycin conjugate could effectively inhibit the biofilm formation of and . In summary, agar-gentamycin conjugates possess good antibacterial activities and may be applied as a new kind of antibacterial material.

摘要

为了开发具有良好抗菌活性且凝胶化和熔化温度降低的琼脂衍生物，通过氧化、席夫碱和还原反应制备了两种固定化庆大霉素含量分别为9.20%和12.68%的琼脂-庆大霉素共轭物，并用傅里叶变换红外光谱仪、氢核磁共振仪和元素分析仪对其进行了表征。结果发现，这些修饰改变了分子间相互作用，导致氧化琼脂的凝胶化和熔化温度降低，而琼脂-庆大霉素共轭物的凝胶化和熔化温度略有升高。抗菌性能的进一步研究表明，这两种琼脂-庆大霉素共轭物具有良好的抗菌活性，且与庆大霉素的用量和固定化率呈正相关。庆大霉素固定化率较高的琼脂-庆大霉素共轭物对[具体菌种1]的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）分别为39.1μg/mL和156.2μg/mL，对[具体菌种2]的MIC和MBC分别为19.5μg/mL和78.1μg/mL。生物膜试验表明，一定浓度的琼脂-庆大霉素共轭物可有效抑制[具体菌种1]和[具体菌种2]的生物膜形成。综上所述，琼脂-庆大霉素共轭物具有良好的抗菌活性，有望作为一种新型抗菌材料应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/e702fe0b3119/polymers-14-02975-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/8d4660e86fbc/polymers-14-02975-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/766a5c0f9ddb/polymers-14-02975-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/625c7847254b/polymers-14-02975-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/232a3eb9e5cc/polymers-14-02975-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/be7449b09d88/polymers-14-02975-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/51a9df6d80ca/polymers-14-02975-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/7b376d9c0020/polymers-14-02975-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/e702fe0b3119/polymers-14-02975-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/8d4660e86fbc/polymers-14-02975-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/766a5c0f9ddb/polymers-14-02975-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/625c7847254b/polymers-14-02975-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/232a3eb9e5cc/polymers-14-02975-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/be7449b09d88/polymers-14-02975-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/51a9df6d80ca/polymers-14-02975-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/7b376d9c0020/polymers-14-02975-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c88/9330791/e702fe0b3119/polymers-14-02975-g008.jpg

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