Department of Oral Pathology, Xiangya Stomatological Hospital & Xiangya School of Stomatology & Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care, Central South University, Hunan, Changsha, China.
Stem Cell Rev Rep. 2022 Dec;18(8):2797-2816. doi: 10.1007/s12015-022-10413-0. Epub 2022 Jul 27.
Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs (ncRNAs), is essential for the regulation of multiple cellular processes. Dental-derived mesenchymal stem cells (DMSCs), a kind of multipotent cells derived from dental tissues, are impactful in regenerative medicine. Recent studies have shown that epigenetic regulation plays a major role in DMSCs. Therefore, exploring how epigenetic regulation is involved in DMSCs may be of guiding significance for tissue repair and regeneration or for exploring more effective treatments. A number of research of ncRNAs in DMSCs have been reported. However, little is known about the roles of DNA methylation and histone modifications in DMSCs. In this review, we summarize the important roles of DNA methylation and histone modifications of the fate of DMSCs.
表观遗传调控，主要涉及 DNA 甲基化、组蛋白修饰和非编码 RNA（ncRNA），对于调节多种细胞过程至关重要。牙源性间充质干细胞（DMSCs）是一种来源于牙组织的多能细胞，在再生医学中具有重要作用。最近的研究表明，表观遗传调控在 DMSCs 中起着重要作用。因此，探讨表观遗传调控如何参与 DMSCs 可能对组织修复和再生具有指导意义，或者对探索更有效的治疗方法具有指导意义。已有大量关于 DMSCs 中 ncRNA 的研究报道。然而，关于 DNA 甲基化和组蛋白修饰在 DMSCs 中的作用知之甚少。在这篇综述中，我们总结了 DNA 甲基化和组蛋白修饰在 DMSCs 命运中的重要作用。
