Sharma Shikha, Bhonde Ramesh
School of Regenerative Medicine, Manipal University, Allalalsandra, Bangalore 560065, India.
Dr D.Y. Patil Vidyapeeth, Pimpri, Pune 411018, India.
Genomics. 2020 Sep;112(5):3615-3623. doi: 10.1016/j.ygeno.2020.04.022. Epub 2020 Apr 28.
Stem cell research has progressed widely and has been receiving a considerable attention for its advantages and drawbacks. Despite their extensive therapeutic potential in regenerative medicine, they are debatable for their genetic and epigenetic stability. In fact lineage specific differentiation is mediated via epigenetic changes in DNA methylation, acetylation, histone modifications etc. Thus epigenetics plays an important role in stem cell biology. For therapeutic interventions stem cells need to be genetically and epigenetically stable for their maximum paracrine secretions for bringing about expected tissue repair and regeneration. In this review we have focused on the current status of genetic and epigenetic stability in stem cells and their importance in regenerative medicine. We have also touched upon the possibility of considering tissue resident mesenchymal stem cells as epigenetic modifiers. This is likely to open a new era in stem cell therapeutic intervention by reversing disease inducing epigenetic changes.
干细胞研究已经取得了广泛进展，其优缺点受到了相当多的关注。尽管它们在再生医学中具有广泛的治疗潜力，但它们在遗传和表观遗传稳定性方面存在争议。事实上，谱系特异性分化是通过DNA甲基化、乙酰化、组蛋白修饰等表观遗传变化介导的。因此，表观遗传学在干细胞生物学中起着重要作用。为了进行治疗干预，干细胞需要在遗传和表观遗传上保持稳定，以实现最大程度的旁分泌分泌，从而实现预期的组织修复和再生。在这篇综述中，我们重点关注了干细胞遗传和表观遗传稳定性的现状及其在再生医学中的重要性。我们还探讨了将组织驻留间充质干细胞视为表观遗传修饰剂的可能性。这可能通过逆转疾病诱导的表观遗传变化，在干细胞治疗干预方面开启一个新时代。
