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忍冬果（L.）通过抑制脂肪酶活性和调节高脂肪饮食喂养小鼠的肠道微生物群来发挥作用。

Honeysuckle Berry ( L.) Inhibits Lipase Activity and Modulates the Gut Microbiota in High-Fat Diet-Fed Mice.

机构信息

Department of Food Science and Biotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea.

Department of Food and Nutrition, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea.

出版信息

Molecules. 2022 Jul 24;27(15):4731. doi: 10.3390/molecules27154731.

DOI:10.3390/molecules27154731
PMID:35897908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9330072/
Abstract

Honeysuckle berry (HB, L.) is an oriental herbal medicine reported to have beneficial effects on metabolic disorders, such as obesity and non-alcoholic fatty liver disease. The fruit part of HB is rich in anthocyanin, a type of polyphenol. Most studies credit the antioxidant and anti-inflammatory properties of HB as the mechanisms of its effectiveness. This study investigated the inhibitory effects of HB on lipase using an in vitro assay and the modulatory effect of HB on gut microbiota in high-fat diet (HFD)-fed mice. HB inhibited pancreatic lipase activity with IC values of approximately 0.47 mg/mL. The fecal triglyceride (TG) levels were higher from the HFD of the HB-fed mice than they were for the control mice. Moreover, the fecal microbiota from the HFD of the HB-fed mice had relatively lower and higher than that from the HFD-only mice. These results suggest that HB modulates gut microbiota composition, which may contribute to body fat reduction. Hence, HB could present a useful agent for treating metabolic diseases through lower TG uptake and the regulation of gut microflora.

摘要

金银花（HB，L.）是一种东方草药，据报道对代谢紊乱有有益的影响，如肥胖和非酒精性脂肪肝疾病。HB 的果实部分富含花青素，这是一种多酚。大多数研究认为 HB 的抗氧化和抗炎特性是其有效性的机制。本研究使用体外测定法研究了 HB 对脂肪酶的抑制作用，并研究了 HB 对高脂肪饮食（HFD）喂养的小鼠肠道微生物群的调节作用。HB 对胰腺脂肪酶活性的抑制 IC 值约为 0.47mg/ml。HB 喂养的 HFD 小鼠的粪便甘油三酯（TG）水平高于对照组小鼠。此外，HB 喂养的 HFD 小鼠的粪便微生物群中的 相对较低，而 相对较高。这些结果表明，HB 调节肠道微生物群组成，这可能有助于减少体脂肪。因此，HB 可以通过降低 TG 吸收和调节肠道微生物群来作为治疗代谢疾病的有用药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/e9a10f1c8fdf/molecules-27-04731-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/0eb69e832fcd/molecules-27-04731-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/470c565bc9db/molecules-27-04731-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/293292e338e2/molecules-27-04731-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/6fa86ff546b8/molecules-27-04731-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/2d4eaafd2693/molecules-27-04731-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/4a51de19b2ce/molecules-27-04731-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/e9a10f1c8fdf/molecules-27-04731-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/0eb69e832fcd/molecules-27-04731-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/470c565bc9db/molecules-27-04731-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/293292e338e2/molecules-27-04731-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/6fa86ff546b8/molecules-27-04731-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/2d4eaafd2693/molecules-27-04731-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/4a51de19b2ce/molecules-27-04731-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400e/9330072/e9a10f1c8fdf/molecules-27-04731-g007.jpg

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