Lee You-Suk, Park Eun-Jung, Kim Sung-Min, Kim Jong-Yeon, Lee Hae-Jeung
Department of Food and Nutrition, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea.
Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea.
Antioxidants (Basel). 2021 Oct 17;10(10):1633. doi: 10.3390/antiox10101633.
Sarcopenic obesity is a combination of sarcopenia and obesity. Although several herbal extracts showed improvement on sarcopenia and obesity, respectively, there are few studies on sarcopenic obesity. (honeysuckle berry, HB) can ameliorate metabolic disorders including obesity. However, its effects on sarcopenic obesity have not been reported yet. Thus, the aim of this study was to investigate whether HB extract might have any beneficial effects on sarcopenic obesity in high-fat diet-induced mice. Forty-eight mice were classified into six groups and treated for eight weeks: (1) NC, normal diet control; (2) HC, high-fat diet control; (3) PC, high-fat diet with orlistat; (4) HB100, high-fat diet with HB extract at 100 mg/kg; (5) HB200, high-fat diet with HB extract at 200 mg/kg; and (6) HB400, high-fat diet with HB extract at 400 mg/kg. Body weight, fat accumulation, muscle mass, muscle strength, and mRNA expression of muscle atrophy were monitored. Compared with the HC group, HB administration showed anti-obesity properties. It reduced body weight gain and modulated serum biochemical parameters and tissue antioxidant enzymes. HB also increased muscle strength and muscle mass of hind legs. In addition, it decreased mRNA expression levels of Atrogin1 and MuRF1 as markers of muscle atrophy but increased PGC1α and SIRT1 as markers of muscle growth. These results suggest that HB might be effective in preventing sarcopenia associated with obesity.
肌少症性肥胖是肌少症和肥胖症的一种组合。尽管几种草药提取物分别对肌少症和肥胖症有改善作用，但关于肌少症性肥胖的研究却很少。（金银花浆果，HB）可以改善包括肥胖症在内的代谢紊乱。然而，其对肌少症性肥胖的影响尚未见报道。因此，本研究的目的是调查HB提取物是否可能对高脂饮食诱导的小鼠的肌少症性肥胖有任何有益作用。将48只小鼠分为六组并进行为期八周的治疗：（1）NC，正常饮食对照组；（2）HC，高脂饮食对照组；（3）PC，高脂饮食加奥利司他；（4）HB100，高脂饮食加100mg/kg的HB提取物；（5）HB200，高脂饮食加200mg/kg的HB提取物；（6）HB400，高脂饮食加400mg/kg的HB提取物。监测体重、脂肪堆积、肌肉质量、肌肉力量和肌肉萎缩的mRNA表达。与HC组相比，给予HB显示出抗肥胖特性。它减少了体重增加并调节了血清生化参数和组织抗氧化酶。HB还增加了后腿的肌肉力量和肌肉质量。此外，它降低了作为肌肉萎缩标志物的Atrogin1和MuRF1的mRNA表达水平，但增加了作为肌肉生长标志物的PGC1α和SIRT1。这些结果表明，HB可能对预防与肥胖相关的肌少症有效。
