University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA; People and Communities Program, Natural Resources Defense Council, 111 Sutter Street, Floor 21, San Francisco, CA, USA.
People and Communities Program, Natural Resources Defense Council, 111 Sutter Street, Floor 21, San Francisco, CA, USA.
Environ Int. 2022 Sep;167:107408. doi: 10.1016/j.envint.2022.107408. Epub 2022 Jul 14.
PFAS (per-and polyfluoroalkyl substances) are a large class of synthetic chemicals widely used in consumer products and industrial processes. The scientific literature on PFAS has increased dramatically in the last decade. Many stakeholders, including regulators, scientists, non-governmental organizations, and concerned individuals could benefit from an efficient way to access the health and toxicological literature related to PFAS.
To create a systematic evidence map of the available peer-reviewed health or toxicological research for 29 PFAS.
A protocol for conducting this systematic evidence map was initially published on Zenodo (Pelch et al. 2019c), then peer reviewed and published in Environment International (Pelch et al. 2019d). PubMed database was searched through January 25, 2021. Studies were screened for inclusion and exclusion according to the Populations, Exposures, Comparators, and Outcomes (PECO) statement. Inclusion criteria were intentionally broad and included any human, animal, and/or in vitro study that investigated exposure to one of the 29 PFAS of interest and a human health or toxicological effect. Selected study details were extracted from included studies as described in the protocol. Study appraisal was not conducted. The included studies and extracted meta-data are freely available in the online, interactive systematic evidence map at https://pfastoxdatabase.org.
Over 15,000 studies were retrieved from the PubMed literature searches. After manual screening, 1,067 studies were identified and included as investigating the health or toxicological effect of one or more PFAS of interest. There were 505 human, 385 animal, and 220 in vitro studies. Summary tables of the extracted data and overall observations are included in this report.
The PFAS-Tox Database is a useful tool for searching, filtering, and identifying peer reviewed research on the health and toxicological effects of the included PFAS. In this summary of the evidence map we provide examples of data gaps and clusters revealed by the database, with the goal of helping direct future research efforts, facilitate systematic reviews (e.g. on immune effects, mixtures of PFAS, or effects of short chain PFAS), inform regulatory risk assessments, and improve opportunities for cross-disciplinary coordination. We also discuss how this tool supports scientists, regulatory agencies, and other individuals by increasing awareness and access to current evidence regarding the health effects associated with PFAS exposure.
PFAS（全氟和多氟烷基物质）是一类广泛应用于消费品和工业过程的合成化学品。过去十年中，有关 PFAS 的科学文献大量增加。包括监管机构、科学家、非政府组织和关注个人在内的许多利益相关者都可以从一种有效的方法中受益，这种方法可以访问与 PFAS 相关的健康和毒理学文献。
创建一个系统的证据图，展示 29 种 PFAS 的现有同行评审健康或毒理学研究。
最初在 Zenodo 上发布了进行这项系统证据图的方案（Pelch 等人，2019c），然后经过同行评审并发表在《环境国际》（Pelch 等人，2019d）上。通过 2021 年 1 月 25 日，在 PubMed 数据库中进行了搜索。根据“人群、暴露、对照和结局（PECO）”声明，对研究进行了纳入和排除筛选。纳入标准是有意放宽的，包括任何研究 PFAS 暴露及其对人类健康或毒理学影响的人类、动物和/或体外研究。从纳入研究中提取了所选研究的详细信息，如方案所述。未进行研究评估。在线交互式系统证据图（https://pfastoxdatabase.org）中提供了包含的研究和提取的元数据。
从 PubMed 文献检索中检索到超过 15000 项研究。经过手动筛选，确定并纳入了 1067 项研究，以调查一种或多种感兴趣的 PFAS 的健康或毒理学效应。其中包括 505 项人类研究、385 项动物研究和 220 项体外研究。本报告包括提取数据的汇总表和总体观察结果。
PFAS-Tox 数据库是搜索、筛选和识别有关所包括 PFAS 的健康和毒理学效应的同行评审研究的有用工具。在本证据图摘要中，我们提供了数据库揭示的数据空白和聚类的示例，旨在帮助指导未来的研究工作、促进系统评价（例如免疫效应、PFAS 混合物或短链 PFAS 效应）、为监管风险评估提供信息，并改善跨学科协调的机会。我们还讨论了该工具如何通过提高对与 PFAS 暴露相关的健康影响的现有证据的认识和获取，为科学家、监管机构和其他个人提供支持。
