Department of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdansk, Poland.
Int J Mol Sci. 2021 Jul 28;22(15):8052. doi: 10.3390/ijms22158052.
Photodynamic therapy (PDT) has become an alternative to standard cancer treatment methods such as surgery, chemotherapy and radiotherapy. The uniqueness of this method relies on the possibility of using various photosensitizers (PS) that absorb and convert light emission in radical oxygen-derived species (ROS). They can be present alone or in the presence of other compounds such as metal organic frameworks (MOFs), non-tubules or polymers. The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs. The use of coordination compounds in PDT has a significant impact on the amount ROS generated, quantum emission efficiency (Φem) and phototoxic index (PI). In this review, we will attempt to systematically review the recent literature and analyze the coordination complexes used as PS in PDT. Finally, we compared the anticancer activities of individual coordination complexes and discuss future perspectives. So far, only a few articles link so many transition metal ion coordination complexes of varying degrees of oxidation, which is why this review is needed by the scientific community to further expand this field worldwide. Additionally, it serves as a convenient collection of important, up-to-date information.
光动力疗法（PDT）已成为手术、化疗和放疗等标准癌症治疗方法的替代方法。这种方法的独特之处在于可以使用各种吸收和转化自由基氧衍生物质（ROS）的光发射的光敏剂（PS）。它们可以单独存在，也可以与金属有机框架（MOF）、非管或聚合物等其他化合物一起存在。DNA 与基于金属的配合物之间的相互作用在新型抗癌药物的开发中起着关键作用。在 PDT 中使用配位化合物对产生的 ROS 量、量子发射效率（Φem）和光毒性指数（PI）有重大影响。在这篇综述中，我们将尝试系统地回顾最近的文献，并分析用作 PDT 中的 PS 的配位化合物。最后，我们比较了单个配位化合物的抗癌活性，并讨论了未来的展望。到目前为止，只有少数几篇文章将如此多的具有不同氧化程度的过渡金属离子配位复合物联系起来，这就是为什么科学界需要这篇综述来进一步在全球范围内扩展这一领域。此外，它还是一个方便的重要、最新信息的集合。
