Hansen K, Rechnitzer C, Pedersen N S, Arpi M, Jessen O
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Feb;263(3):348-50. doi: 10.1016/s0176-6724(87)80090-1.
We studied 23 patients with borrelia meningitis, a tick-borne spirochetosis increasingly recognized in Denmark. The disease showed a seasonal incidence from June to December. Twenty one patients experienced a painful sensory radiculitis, in 17 cases followed by a predominantly cranial mononeuritis multiplex mainly affecting the facial nerve (Bannwarth's syndrome). Three patients had focal CNS involvement in the form of a transverse myelitis, a focal encephalitis and a disseminated leucoencephalopathy, respectively. The CSF showed invariably lymphocytic pleocytosis and elevated spinal protein concentration. Measuring borrelia antibodies in the CSF seemed of higher diagnostic sensitivity than in serum. Penicillin therapy was effective even in cases with focal CNS lesions.
我们研究了23例莱姆病脑膜炎患者，这是一种在丹麦日益被认识到的蜱传螺旋体病。该病的发病有季节性，从6月至12月。21例患者经历了疼痛性感觉神经根炎，其中17例随后出现主要累及面神经的以颅神经多发性单神经炎为主的病变（班恩沃思综合征）。3例患者分别以横贯性脊髓炎、局灶性脑炎和播散性白质脑病的形式出现中枢神经系统局灶性受累。脑脊液始终显示淋巴细胞增多和脊髓蛋白浓度升高。检测脑脊液中的莱姆病抗体似乎比检测血清具有更高的诊断敏感性。青霉素治疗即使在有中枢神经系统局灶性病变的病例中也有效。
