Permatasari Happy Kurnia, Nurkolis Fahrul, Hardinsyah Hardinsyah, Taslim Nurpudji Astuti, Sabrina Nindy, Ibrahim Faisal Maulana, Visnu Jodi, Kumalawati Dian Aruni, Febriana Sri Awalia, Sudargo Toto, Tanner Melvin Junior, Kurniatanty Isma, Yusuf Vincentius Mario, Rompies Ronald, Bahar Muhammad Rahimi, Holipah Holipah, Mayulu Nelly
Department of Biochemistry and Biomolecular, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
Department of Biological Sciences, Sunan Kalijaga State Islamic University, Yogyakarta, Indonesia.
Front Nutr. 2022 Jul 14;9:939073. doi: 10.3389/fnut.2022.939073. eCollection 2022.
Obesity is associated with an accelerated aging process, which prevents healthy aging. Both obesity and aging were manifested in the peroxisome proliferator-activated receptor-γ coactivator α (PGC-1α) level. These studies fulfill the scientific gap in assembled pharmacological activity assay of done in a previous preclinical trial. Six major compounds from sea grape () extract were evaluated using an approach against human pancreatic , , and to predict prospective anti-obesity candidates. The inhibitory activity of the extract reached 90.30 ± 0.40%, 1.75% lower than orlistat. The inhibitory assay of the extract was 84.07 ± 5.28%, while the inhibitory activity against was 81.67 ± 1.54%; both were lower than acarbose. We observe the effect of extract as anti-obesity with anti-aging by evaluating the obesity parameters in the human body for a 4-week period. There was a significant decrease in blood glucose, total cholesterol, low-density lipoprotein (LDL), triglycerides (TG), waist circumference, waist-hip ratio, and body weight ( < 0.05); PGC-1α and high-density lipoprotein (HDL) increased significantly ( = 0.000), in Group B when compared with Group A. Our study revealed that sea grape extract is a potent anti-obesity with an anti-aging reagent that does not produce any significant adverse effects.
肥胖与加速衰老过程相关，这会阻碍健康衰老。肥胖和衰老都体现在过氧化物酶体增殖物激活受体γ共激活因子α（PGC-1α）水平上。这些研究填补了先前临床前试验中进行的组合药理活性测定方面的科学空白。使用一种方法对海葡萄提取物中的六种主要化合物进行了评估，以对抗人胰腺、、和，从而预测潜在的抗肥胖候选物。提取物的抑制活性达到90.30±0.40%，比奥利司他低1.75%。提取物的抑制试验为84.07±5.28%，而对的抑制活性为81.67±1.54%；两者均低于阿卡波糖。通过在为期4周的时间内评估人体中的肥胖参数，我们观察了海葡萄提取物作为具有抗衰老作用的抗肥胖药物的效果。与A组相比，B组的血糖、总胆固醇、低密度脂蛋白（LDL）、甘油三酯（TG）、腰围、腰臀比和体重显著降低（<0.05）；PGC-1α和高密度脂蛋白（HDL）显著增加（=0.000）。我们的研究表明，海葡萄提取物是一种有效的抗肥胖药物，同时也是一种抗衰老试剂，不会产生任何显著的不良反应。
