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改性细菌纤维素在生物医学中的应用。

Modified Bacterial Cellulose for Biomedical Applications.

机构信息

Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore, 138634, Singapore.

Department of Material Science Engineering, National University of Singapore (NUS), 9 Engineering Drive 1, Singapore, 117575, Singapore.

出版信息

Chem Asian J. 2022 Oct 4;17(19):e202200598. doi: 10.1002/asia.202200598. Epub 2022 Aug 18.

Abstract

Bacterial cellulose, or microbial cellulose, had gained tremendous interest as a hydrogel material for biomedical purposes in the recent years. It has many intrinsic physiological properties like fibrous nature, ultrafine 3D nanostructure network, high water holding capacity, excellent mechanical properties, biocompatibility and biodegradability that allow for the use of such purposes, and the lacking properties can be easily supplemented or enhanced by modifications. In this review, some of the biomedical applications that uses bacterial cellulose are discussed. These include wound healing, drug delivery, tissue engineering and tumor cell and cancer therapy. In each section, different modifications of BC are showcased and examined on how they benefit the application. Finally, key takeaways on these modifications are also deliberated.

摘要

近年来,细菌纤维素(或微生物纤维素)作为一种水凝胶材料,在生物医学领域引起了极大的关注。它具有许多内在的生理特性,如纤维状、超精细的 3D 纳米结构网络、高持水能力、优异的机械性能、生物相容性和可生物降解性,这些特性使其能够应用于这些领域,而缺乏的特性可以通过修饰很容易地补充或增强。在这篇综述中,讨论了一些利用细菌纤维素的生物医学应用。这些应用包括伤口愈合、药物输送、组织工程以及肿瘤细胞和癌症治疗。在每个部分中,展示了不同的 BC 修饰,并研究了它们如何使应用受益。最后,还对这些修饰进行了关键的讨论。

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