Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China.
Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province, China; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu Province 210037, China.
Carbohydr Polym. 2022 Feb 15;278:118995. doi: 10.1016/j.carbpol.2021.118995. Epub 2021 Dec 10.
Driven by its excellent physical and chemical properties, BC (bacterial cellulose) has achieved significant progress in the last decade, rendering with many novel applications. Due to its resemblance to the structure of extracellular matrix, BC-based biomaterials have been widely explored for biomedical applications such as tissue engineering and drug delivery. The recent advances in nanotechnology endow further modifications on BC and generate BC-based composites for different applications. This article presents a review on the research advancement on BC-based biomaterials from fabrication methods to biomedical applications, including wound dressing, artificial skin, vascular tissue engineering, bone tissue regeneration, drug delivery, and other applications. The preparation of these materials and their potential applications are reviewed and summarized. Important factors for the applications of BC in biomedical applications including degradation and pore structure characteristic are discussed in detail. Finally, the challenges in future development and potential advances of these materials are also discussed.
得益于其出色的物理和化学性质，BC（细菌纤维素）在过去十年中取得了重大进展，具有许多新颖的应用。由于其结构类似于细胞外基质，基于 BC 的生物材料已被广泛探索用于组织工程和药物输送等生物医学应用。纳米技术的最新进展进一步对 BC 进行了修饰，并为不同的应用生成了基于 BC 的复合材料。本文综述了基于 BC 的生物材料从制备方法到生物医学应用的研究进展，包括伤口敷料、人造皮肤、血管组织工程、骨组织再生、药物输送和其他应用。综述了这些材料的制备及其潜在应用。详细讨论了 BC 在生物医学应用中的降解和孔隙结构特征等重要因素。最后，还讨论了这些材料未来发展的挑战和潜在进展。
