Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Department of Periodontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Periodontol 2000. 2022 Oct;90(1):125-137. doi: 10.1111/prd.12453. Epub 2022 Aug 1.
Periodontitis is a disease characterized by tooth-associated microbial biofilms that drive chronic inflammation and destruction of periodontal-supporting tissues. In some individuals, disease progression can lead to tooth loss. A similar condition can occur around dental implants in the form of peri-implantitis. The immune response to bacterial challenges is not only influenced by genetic factors, but also by environmental factors. Epigenetics involves the study of gene function independent of changes to the DNA sequence and its associated proteins, and represents a critical link between genetic and environmental factors. Epigenetic modifications have been shown to contribute to the progression of several diseases, including chronic inflammatory diseases like periodontitis and peri-implantitis. This review aims to present the latest findings on epigenetic influences on periodontitis and to discuss potential mechanisms that may influence peri-implantitis, given the paucity of information currently available.
牙周炎是一种以牙齿相关微生物生物膜为特征的疾病，可导致慢性炎症和牙周支持组织的破坏。在某些个体中，疾病的进展可能导致牙齿丧失。类似的情况也可能在种植牙周围以种植体周围炎的形式出现。对细菌挑战的免疫反应不仅受遗传因素的影响，还受环境因素的影响。表观遗传学涉及研究基因功能，而不考虑 DNA 序列及其相关蛋白的变化，并且是遗传和环境因素之间的关键联系。已经表明，表观遗传修饰有助于几种疾病的进展，包括慢性炎症性疾病，如牙周炎和种植体周围炎。本综述旨在介绍牙周炎的最新表观遗传学影响，并讨论可能影响种植体周围炎的潜在机制，因为目前可用的信息很少。
