Little R E, Sing C F
Am J Hum Genet. 1987 Jun;40(6):512-26.
Path-analytic techniques were used to demonstrate a significant influence of both fetal genes and maternal environment on birth weight in a sample of infants born to primarily white, middle-class, nonsmoking mothers. If the mother smoked before conception, however, the expression of the fetal birth-weight genes in males was significantly reduced. Multiparity was associated with an increase in genetic variance. This is the first report that genetic influences on birth weight are dependent on the environmental conditions imposed on the fetus by the mother.
路径分析技术被用于证明在主要为白人、中产阶级、不吸烟母亲所生婴儿的样本中，胎儿基因和母亲环境对出生体重均有显著影响。然而，如果母亲在受孕前吸烟，男性胎儿出生体重基因的表达则会显著降低。多胎妊娠与遗传方差增加有关。这是第一份关于出生体重受遗传影响取决于母亲施加给胎儿的环境条件的报告。
