2型糖尿病患者及超重/肥胖个体中的循环短链脂肪酸
Circulating short-chain fatty acids in type 2 diabetic patients and overweight/obese individuals.
作者信息
Salamone Dominic, Costabile Giuseppina, Corrado Alessandra, Della Pepa Giuseppe, Vitale Marilena, Giacco Rosalba, Luongo Delia, Testa Roberta, Rivellese Angela Albarosa, Annuzzi Giovanni, Bozzetto Lutgarda
机构信息
Department of Clinical Medicine and Surgery, "Federico II" University, Sergio Pansini, 5, 80131, Naples, Italy.
Task Force on Microbiome Studies, University of Naples "Federico II", Naples, Italy.
出版信息
Acta Diabetol. 2022 Dec;59(12):1653-1656. doi: 10.1007/s00592-022-01934-8. Epub 2022 Aug 3.
AIM
aim of the study was to evaluate serum short chain fatty acids (SCFA) concentrations in patients with Type 2 diabetes (T2D) and overweight/obese individuals.
METHODS
In forty-three patients with T2D and twenty-eight overweight/obese patients SCFA were determined by Gas-Chromatography/Flame Ionization Detector (GC/FID).
RESULTS
Acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese in the unadjusted model. Adjusting for all variables only propionic acid remained significantly lower in T2D.
CONCLUSION
Only reduction of propionic acid was closely related to diabetes itself, regardless of all other factors.
目的
本研究旨在评估2型糖尿病（T2D）患者和超重/肥胖个体的血清短链脂肪酸（SCFA）浓度。
方法
采用气相色谱/火焰离子化检测器（GC/FID）测定43例T2D患者和28例超重/肥胖患者的SCFA。
结果
在未调整模型中，与超重/肥胖患者相比，T2D患者的乙酸、丙酸、丁酸和总SCFA显著降低。在对所有变量进行调整后，仅丙酸在T2D患者中仍显著较低。
结论
无论所有其他因素如何，仅丙酸的降低与糖尿病本身密切相关。
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