He Ming-Chao, Feng Rui, Wang Jing, Xia Shi-Hui, Wang Yong-Jun, Zhang Yan
Spine Disease Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China.
Front Aging Neurosci. 2022 Jul 18;14:950143. doi: 10.3389/fnagi.2022.950143. eCollection 2022.
The molecular pathology involved in the development of depression is complex. Many signaling pathways and transcription factors have been demonstrated to display crucial roles in the process of depression occurrence and development. The multi-components and multi-targets of Traditional Chinese Medicine (TCM) are uniquely advantageous in the prevention and treatment of chronic diseases. This review summarizes the pharmacological regulations of natural products from TCM in the prevention and treatment of depression from the aspects of transcription factors (CREB, NF-κB, Nrf2) and molecular signaling pathways (BDNF-TrkB, MAPK, GSK-3β, TLR-4).
抑郁症发生发展过程中涉及的分子病理学十分复杂。许多信号通路和转录因子已被证明在抑郁症的发生发展过程中发挥着关键作用。中药的多成分、多靶点在慢性病的防治方面具有独特优势。本综述从转录因子（CREB、NF-κB、Nrf2）和分子信号通路（BDNF-TrkB、MAPK、GSK-3β、TLR-4）方面总结了中药天然产物在抑郁症防治中的药理调控作用。
