Soran Handrean, Schofield Jonathan D, Durrington Paul N
Cardiovascular Research Group, Core Technology Facility, University of Manchester Manchester, UK ; Cardiovascular Trials Unit, Central Manchester University Hospitals NHS Foundation Trust Manchester, UK.
Cardiovascular Research Group, Core Technology Facility, University of Manchester Manchester, UK.
Front Pharmacol. 2015 Oct 16;6:222. doi: 10.3389/fphar.2015.00222. eCollection 2015.
High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly, HDL actually metabolizes lipid hydroperoxides preventing their accumulation on low-density lipoprotein (LDL), thus impeding its atherogenic structural modification. A number of candidates have been suggested to be responsible for HDL's antioxidant function, with paraoxonase-1 (PON1) perhaps the most prominent. Here we review the evidence for HDL anti-oxidative function and the potential contributions of apolipoproteins, lipid transfer proteins, paraoxonases and other enzymes associated with HDL.
高密度脂蛋白（HDL）为脂质过氧化物和溶血磷脂通过肝脏清除受体转运至肝脏提供了一条途径。或许更重要的是，HDL实际上可代谢脂质氢过氧化物，防止其在低密度脂蛋白（LDL）上积聚，从而阻碍其致动脉粥样硬化的结构修饰。已有多种候选物质被认为与HDL的抗氧化功能有关，其中对氧磷酶-1（PON1）可能最为突出。在此，我们综述了HDL抗氧化功能的证据以及载脂蛋白、脂质转运蛋白、对氧磷酶和其他与HDL相关酶的潜在作用。
