Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Chirality. 2022 Nov;34(11):1419-1436. doi: 10.1002/chir.23499. Epub 2022 Aug 4.
Stereoselective chiral molecules are responsible for specific biological functions in nature. At present, more than half of the prescribed drugs are chiral. Living organisms display divergent pharmacological responses to the enantiomers, leading to altered toxicity, pharmacokinetics, and pharmacodynamics. Thus, chiral analysis, separation, and extraction are crucial for ensuring enantiomeric purity to develop safe and effective medication. In recent times, metal-organic frameworks (MOFs) with appealing structures are gaining importance because of their fascinating properties as a sorbent and stationary phase. MOFs are crystalline porous solid materials built by interconnecting metal ions or clusters and organic linkers. This review explores the advancements in MOFs for the isolation and separation of chiral active pharmaceutical drugs.
手性立体选择性分子在自然界中负责特定的生物功能。目前，超过一半的规定药物是手性的。生物体对映体表现出不同的药理反应，导致毒性、药代动力学和药效学的改变。因此，手性分析、分离和提取对于确保对映体纯度以开发安全有效的药物至关重要。近年来，具有吸引人结构的金属有机骨架（MOFs）因其作为吸附剂和固定相的迷人性质而变得越来越重要。MOFs 是由连接金属离子或簇和有机连接体的晶体多孔固体材料组成的。这篇综述探讨了 MOFs 在分离和分离手性活性药物方面的进展。
