Department of Pharmaceutics & Pharmaceutical Technology,Faculty of Pharmacy, Yarmouk University, PO Box 566, Irbid, 21163, Jordan.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, India.
Ther Deliv. 2022 Jun;13(6):321-338. doi: 10.4155/tde-2021-0091. Epub 2022 Aug 4.
Protein nanomaterials are well-defined, hollow protein nanoparticles comprised of virus capsids, virus-like particles, ferritin, heat shock proteins, chaperonins and many more. Protein-based nanomaterials are formed by the self-assembly of protein subunits and have numerous desired properties as drug-delivery vehicles, including being optimally sized for endocytosis, nontoxic, biocompatible, biodegradable and functionalized at three separate interfaces (external, internal and intersubunit). As a result, protein nanomaterials have been intensively investigated as functional entities in bionanotechnology, including drug delivery, nanoreactors and templates for organic and inorganic nanomaterials. Several variables influence efficient administration, particularly active targeting, cellular uptake, the kinetics of the release and systemic elimination. This review examines the wide range of medicines, loading/release processes, targeted therapies and treatment effectiveness.
蛋白质纳米材料是由病毒衣壳、类病毒粒子、铁蛋白、热休克蛋白、伴侣蛋白等组成的具有明确结构的中空蛋白质纳米颗粒。基于蛋白质的纳米材料是由蛋白质亚基自组装形成的，具有许多作为药物输送载体的理想特性，包括最适合内吞作用的大小、无毒、生物相容性、可生物降解和在三个独立界面（外部、内部和亚基间）进行功能化。因此，蛋白质纳米材料作为生物纳米技术中的功能实体受到了广泛的研究，包括药物输送、纳米反应器和有机和无机纳米材料的模板。有几个变量会影响有效给药，特别是主动靶向、细胞摄取、释放动力学和系统消除。本文综述了广泛的药物、加载/释放过程、靶向治疗和治疗效果。
