Aldihan Rema, Alsubait Norah, Alhaddab Mohammed
College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ministry of Health, Al Iman General Hospital, Riyadh, Saudi Arabia.
AME Case Rep. 2022 Jul 25;6:26. doi: 10.21037/acr-22-2. eCollection 2022.
Cutaneous lymphadenoma (CL) is a rare benign epithelial neoplasm. It presents as skin-colored nodule in the head and neck area. CL is an uncommon condition with less than 60 cases reported in the literature and very rare occurrence in the Asian population; it has never been previously reported in the Arabian gulf countries. We report the first case of CL in a young Saudi female.
A 28-year-old Saudi female presented with an asymptomatic skin lesion on her forehead that first appeared eight years ago. Physical examination showed a 3 mm × 3.4 mm solitary, nontender, firm, skin-colored to pink nodule with overlying telangiectasia. A biopsy was taken, and histopathology findings revealed epithelial nests of uniform, small basaloid cells with some peripheral palisading; a fibrotic stroma; and Lympho-histiocytic inflammatory infiltrates. No retraction artifacts, atypia or necrosis were observed. These findings are consistent with CL. The lesion was fully excised by skin punch biopsy without any residual tumor. No recurrence was observed after 1 year follow-up.
CL presents a diagnostic pitfall, and many dermatologists fail to recognize it in the initial clinical impression. Moreover, although CL is a rare and benign tumor, it must be in the differential diagnosis of any asymptomatic skin nodule in the head and neck area.
皮肤淋巴结瘤(CL)是一种罕见的良性上皮性肿瘤。它表现为头颈部皮肤颜色的结节。CL是一种不常见的疾病,文献报道不足60例,在亚洲人群中极为罕见;此前在阿拉伯海湾国家从未有过报道。我们报告了一名年轻沙特女性的首例CL病例。
一名28岁的沙特女性,前额出现一个无症状皮肤病变,该病变于8年前首次出现。体格检查发现一个3毫米×3.4毫米的孤立、无压痛、质地坚硬、皮肤颜色至粉红色的结节,伴有表面毛细血管扩张。进行了活检,组织病理学检查结果显示为均匀的小基底样细胞上皮巢,周围有一些栅栏状排列;有纤维化间质;以及淋巴细胞 - 组织细胞性炎症浸润。未观察到退缩假象、异型性或坏死。这些发现符合CL。通过皮肤打孔活检将病变完全切除,无任何残留肿瘤。随访1年后未观察到复发。
CL存在诊断陷阱,许多皮肤科医生在初始临床印象中未能识别它。此外,尽管CL是一种罕见的良性肿瘤,但在对头颈部任何无症状皮肤结节进行鉴别诊断时都必须考虑到它。