State Key laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
College of Life Science and Food Engineering, Hebei University of Engineering, Handan, People's Republic of China.
Emerg Microbes Infect. 2022 Dec;11(1):2069-2079. doi: 10.1080/22221751.2022.2109514.
The enteroinvasive bacterium is known as a highly host-adapted human pathogen. There had been no known other reservoirs reported until recently. Here 34 isolates obtained from animals (yaks, dairy cows and beef cattle) from 2016 to 2017 and 268 human isolates from China were sequenced to determine the relationships between animal and human isolates and infer the evolutionary history of animal-associated . The 18 animal isolates (15 yak and 3 beef cattle isolates) in PG1 were separated into 4 lineages, and the 16 animal isolates (1 yak, 5 beef cattle and 10 dairy cow isolates) in PG3 were clustered in 8 lineages. The most recent human isolates from China belonged to PG3 whereas Chinese isolates from the 1950s-1960s belonged to PG1. PG1 may has been transmitted to the yaks during PG1 circulation in the human population in China and has remained in the yak population since, while PG3 in animals were likely recent transmissions from the human population. Increased stability of the large virulence plasmid and acquisition of abundant antimicrobial resistance determinants may have enabled PG3 to expand globally and replaced PG1 in China. Our study confirms that animals may act as a reservoir for . Genomic analysis revealed the evolutionary history of multiple lineages in animals and humans in China. However, further studies are required to determine the public health threat of from animals.
肠侵袭性细菌被认为是一种高度适应宿主的人类病原体。直到最近，才报告有其他已知的宿主。本研究对 2016 年至 2017 年期间从动物（牦牛、奶牛和肉牛）中获得的 34 株分离株和中国的 268 株人类分离株进行了测序，以确定动物和人类分离株之间的关系，并推断动物相关的进化史。PG1 中的 18 株动物分离株（15 株牦牛和 3 株肉牛分离株）分为 4 个谱系，PG3 中的 16 株动物分离株（1 株牦牛、5 株肉牛和 10 株奶牛分离株）聚集在 8 个谱系中。中国最近的人类分离株属于 PG3，而中国 20 世纪 50 年代至 60 年代的分离株属于 PG1。PG1 可能在 PG1 在中国人群中传播期间传播给了牦牛，并从那时起一直存在于牦牛群体中，而动物中的 PG3 可能是最近从人群中传播到动物的。大毒力质粒的稳定性增加和丰富的抗菌药物抗性决定因素的获得可能使 PG3 能够在全球范围内扩张，并在中国取代 PG1。我们的研究证实，动物可能是 的宿主。基因组分析揭示了中国动物和人类中多个 谱系的进化史。然而，需要进一步研究来确定动物 对公共卫生的威胁。
