Billowria Koushal, Ali Rouchan, Rangra Naresh Kumar, Kumar Ram, Chawla Pooja A
Department of Pharmaceutical Analysis, ISF College of Pharmacy, Moga, India.
Crit Rev Anal Chem. 2024 Aug;54(5):1002-1016. doi: 10.1080/10408347.2022.2105641. Epub 2022 Aug 5.
Flavonoids are a diversified group of natural substances which were discovered to provide a variety of health benefits in human beings. Vegetables, fruits, wine and tea are the primary flavonoid dietary sources for humans and as the flavonoids are so closely connected to human dietary items and health, it is vital to explore the structural-activity connection. The arrangement, replacement of functional groups, and total number of hydroxyl groups around flavonoid's nucleus structure affect their biological activity, metabolism, and bioavailability. Various flavonoids have been proven to have hepatoprotective properties, that help in the prevention of coronary heart disease. Similarly, these flavonoids also possess anticancer, and anti-inflammatory activities. Flavonoids have been found to have a functional and structural link with their enzyme inhibitory action, that appears to have antiviral effect through acting as antioxidants, damaging cell membranes, blocking enzymes, activating mechanisms of host self-defense, and limiting virus penetration and attaching to cells. Identification, characterization, isolation, and biological role of flavonoids, as well as their uses on health advantages, are all major topics in research and development currently. This review represents a summary of various sources of flavonoids, class, subclass, their chemical structures, biological activities, the pharmacokinetics of flavonoids and various analytical, bioanalytical and electrochemical methods for determination of flavonoids from different matrices.
黄酮类化合物是一类多样化的天然物质，人们发现它们对人类健康有多种益处。蔬菜、水果、葡萄酒和茶是人类黄酮类化合物的主要膳食来源，由于黄酮类化合物与人类饮食和健康密切相关，探索其构效关系至关重要。黄酮类化合物核结构周围的排列、官能团取代以及羟基总数会影响它们的生物活性、代谢和生物利用度。各种黄酮类化合物已被证明具有保肝特性，有助于预防冠心病。同样，这些黄酮类化合物还具有抗癌和抗炎活性。已发现黄酮类化合物与其酶抑制作用存在功能和结构联系，其似乎通过充当抗氧化剂、破坏细胞膜、阻断酶、激活宿主自我防御机制以及限制病毒渗透和附着于细胞而具有抗病毒作用。黄酮类化合物的鉴定、表征、分离及其生物学作用，以及它们在健康益处方面的用途，都是目前研发中的主要课题。本综述总结了黄酮类化合物的各种来源、类别、亚类、化学结构、生物活性、黄酮类化合物的药代动力学以及用于测定不同基质中黄酮类化合物的各种分析、生物分析和电化学方法。
