无痛胃肠镜麻醉中患者术中不良反应、手术、复苏以及满意度比较及西普罗和丙泊酚的临床价值。
Comparison and Clinical Value of Ciprofol and Propofol in Intraoperative Adverse Reactions, Operation, Resuscitation, and Satisfaction of Patients under Painless Gastroenteroscopy Anesthesia.
机构信息
The Second People's Hospital of Yibin, Department of Anesthesiology, Yibin, China.
Department of Critical Care Medicine, The 2nd Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu 610051, Sichuan Province, China.
出版信息
Contrast Media Mol Imaging. 2022 Jul 18;2022:9541060. doi: 10.1155/2022/9541060. eCollection 2022.
OBJECTIVE
To investigate the comparison and clinical value of ciprofol and propofol for painless gastroenteroscopy anesthesia in terms of intraoperative adverse reactions, operation, resuscitation, and satisfaction of patients.
METHODS
A total of 96 patients who underwent painless gastroenteroscopy anesthesia in our hospital from June 2021 to January 2022 were enrolled. The cases were randomly assigned into research group and control group. The control group received propofol anesthesia ( = 49), and the research group received ciprofol anesthesia ( = 47). The patients, physician satisfaction, vital signs, incidence of adverse reactions, anesthetic first dose, additional time, additional dose, total dose, induction time, insertion time, operation time, awake time, orientation recovery time, leaving room time, and injection pain score were compared.
RESULTS
The overall satisfaction of the study group was higher than that of the control group ( < 0.05). After taking medicine, the score of 1 min and MAP in the study group were higher than those in the control group. The incidence of adverse reactions in the study group was lower than that in the control group ( < 0.05). The satisfaction of doctors in the study group was higher than that in the control group ( < 0.05). The anesthesia induction time, intubation time, operation time, awake time, orientation recovery time, and leaving room time in the study group were significantly longer than those in the control group ( < 0.05). The incidence and degree of injection pain in the propofol group were significantly lower than those in the propofol group ( < 0.05).
CONCLUSION
In painless gastroenteroscopy, compared with propofol, ciprofol is equally safe and effective for patients and will not cause early cognitive dysfunction after operation, which is a good choice in painless gastroenteroscopy anesthesia. In addition, ciprofol has significant advantages in patient and physician satisfaction, especially in injection pain. This trial is registered with ChiCTR2100045400.
目的
比较并探讨西普罗酚与丙泊酚用于无痛胃镜麻醉的术中不良反应、手术、复苏及患者满意度的临床价值。
方法
选取 2021 年 6 月至 2022 年 1 月我院收治的 96 例行无痛胃镜麻醉的患者，采用随机数字表法将其分为研究组和对照组，每组 47 例。对照组给予丙泊酚麻醉，研究组给予西普罗酚麻醉。比较两组患者、麻醉医师满意度、生命体征、不良反应发生率、麻醉首剂量、追加时间、追加剂量、总剂量、诱导时间、插入时间、手术时间、苏醒时间、定向恢复时间、出室时间、注射疼痛评分。
结果
研究组患者满意度高于对照组（<0.05）。用药后 1min 及 MAP 研究组高于对照组（<0.05）。研究组不良反应发生率低于对照组（<0.05）。研究组麻醉医师满意度高于对照组（<0.05）。研究组麻醉诱导时间、插管时间、手术时间、苏醒时间、定向恢复时间、出室时间长于对照组（<0.05）。丙泊酚组注射疼痛发生率及程度均低于丙泊酚组（<0.05）。
结论
在无痛胃镜中，与丙泊酚相比，西普罗酚用于患者同样安全有效，且术后不会引起早期认知功能障碍，是无痛胃镜麻醉的良好选择。此外，西普罗酚在患者和医生满意度方面具有显著优势，尤其是在注射疼痛方面。本试验已在中国临床试验注册中心注册，注册号 ChiCTR2100045400。
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