Mocellin Michel Carlos, Pastore e Silva Juliana de Aguiar, Camargo Carolina de Quadros, Fabre Maria Emília de Souza, Gevaerd Scheila, Naliwaiko Katya, Moreno Yara Maria Franco, Nunes Everson Araújo, Trindade Erasmo Benicio Santos de Moraes
Post-Graduate Program of Nutrition, Department of Nutrition, Federal University of Santa Catarina, Reitor João David Ferreira Lima Campus, Trindade, Florianópolis, SC, 88040-970, Brazil.
Lipids. 2013 Sep;48(9):879-88. doi: 10.1007/s11745-013-3816-0. Epub 2013 Jul 26.
Previous studies have shown that n-3 polyunsaturated fatty acids n-3 (n-3 PUFA) have several anticancer effects, especially attributed to their ability to modulate a variety of genomic and immune responses. In this context, this randomized, prospective, controlled clinical trial was conducted in order to check whether supplementation of 2 g/day of fish oil for 9 weeks alters the production of inflammatory markers, the plasma fatty acid profile and the nutritional status in patients with colorectal cancer (CRC). Eleven adults with CRC in chemotherapy were randomized into two groups: (a) supplemented (SG) daily with 2 g/day of encapsulated fish oil [providing 600 mg/day of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA)] for 9 weeks (n = 6), and (b) control (CG) (n = 5). All outcomes were evaluated on the day before the first chemotherapy session and 9 weeks later. Plasma TNF-α, IL-1β, IL-10 and IL-17A, the pro/anti-inflammatory balance (ratio TNF-α/IL-10 and IL-1β/IL10) and serum albumin, showed no significant changes between times and study groups (p > 0.05). C-reactive protein (CRP) and the CRP/albumin ratio showed opposite behavior in groups, significantly reducing their values in SG (p < 0.05). Plasma proportions of EPA and DHA increased 1.8 and 1.4 times, respectively, while the ARA reduced approximately 0.6 times with the supplementation (9 weeks vs baseline, p < 0.05). Patients from SG gained 1.2 kg (median) while the CG lost -0.5 kg (median) during the 9 weeks of chemotherapy (p = 0.72). These results demonstrate that 2 g/day of fish oil for 9 weeks of chemotherapy improves CRP values, CRP/albumin status, plasma fatty acid profile and potentially prevents weight loss during treatment.
先前的研究表明，n-3多不饱和脂肪酸（n-3 PUFA）具有多种抗癌作用，这尤其归因于它们调节多种基因组和免疫反应的能力。在此背景下，开展了这项随机、前瞻性、对照临床试验，以检验每天补充2克鱼油，持续9周，是否会改变结直肠癌（CRC）患者体内炎症标志物的产生、血浆脂肪酸谱以及营养状况。11名正在接受化疗的成年CRC患者被随机分为两组：（a）补充组（SG），每天补充2克胶囊鱼油[提供600毫克/天的二十碳五烯酸（EPA）+二十二碳六烯酸（DHA）]，持续9周（n = 6）；（b）对照组（CG）（n = 5）。所有结果均在首次化疗疗程前一天和9周后进行评估。血浆肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-10（IL-10）和白细胞介素-17A、促炎/抗炎平衡（TNF-α/IL-10和IL-1β/IL10比值）以及血清白蛋白，在不同时间点和研究组之间均无显著变化（p>0.05）。C反应蛋白（CRP）和CRP/白蛋白比值在两组中的表现相反，SG组的值显著降低（p<0.05）。补充鱼油后，血浆中EPA和DHA的比例分别增加了1.8倍和1.4倍，而花生四烯酸（ARA）减少了约0.6倍（9周与基线相比，p<0.05）。在9周的化疗期间，SG组患者体重增加了1.2千克（中位数），而CG组患者体重减轻了0.5千克（中位数）（p = 0.72）。这些结果表明，化疗期间每天补充2克鱼油，持续9周，可改善CRP值、CRP/白蛋白状况、血浆脂肪酸谱，并可能预防治疗期间的体重减轻。
