Ramlee Syafiq, Hulse David, Bernatowicz Kinga, Pérez-López Raquel, Sala Evis, Aloj Luigi
Department of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.
Radiomics Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain.
Cancers (Basel). 2022 Jul 27;14(15):3656. doi: 10.3390/cancers14153656.
The tumour immune microenvironment influences the efficacy of immune checkpoint inhibitors. Within this microenvironment are CD8-expressing tumour-infiltrating lymphocytes (CD8 TILs), which are an important mediator and marker of anti-tumour response. In practice, the assessment of CD8 TILs via tissue sampling involves logistical challenges. Radiomics, the high-throughput extraction of features from medical images, may offer a novel and non-invasive alternative. We performed a systematic review of the available literature reporting radiomic signatures associated with CD8 TILs. We also aimed to evaluate the methodological quality of the identified studies using the Radiomics Quality Score (RQS) tool, and the risk of bias and applicability with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Articles were searched from inception until 31 December 2021, in three electronic databases, and screened against eligibility criteria. Twenty-seven articles were included. A wide variety of cancers have been studied. The reported radiomic signatures were heterogeneous, with very limited reproducibility between studies of the same cancer group. The overall quality of studies was found to be less than desirable (mean RQS = 33.3%), indicating a need for technical maturation. Some potential avenues for further investigation are also discussed.
肿瘤免疫微环境会影响免疫检查点抑制剂的疗效。在这种微环境中存在表达CD8的肿瘤浸润淋巴细胞（CD8 TILs），它们是抗肿瘤反应的重要介质和标志物。在实际操作中，通过组织采样评估CD8 TILs存在后勤保障方面的挑战。放射组学，即从医学图像中高通量提取特征，可能提供一种新颖的非侵入性替代方法。我们对报告与CD8 TILs相关的放射组学特征的现有文献进行了系统综述。我们还旨在使用放射组学质量评分（RQS）工具评估已识别研究的方法学质量，并使用诊断准确性研究质量评估（QUADAS - 2）工具评估偏倚风险和适用性。从数据库建库至2021年12月31日在三个电子数据库中检索文章，并根据纳入标准进行筛选。共纳入27篇文章。研究了多种癌症。所报告的放射组学特征具有异质性，同一癌症组的研究之间的可重复性非常有限。研究的总体质量被发现不尽人意（平均RQS = 33.3%），表明需要技术成熟。还讨论了一些进一步研究的潜在途径。
