Department of Pediatrics, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi 61344, Taiwan.
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Int J Mol Sci. 2022 Jul 27;23(15):8294. doi: 10.3390/ijms23158294.
Hypertension is an important public health challenge, affecting up to 30-50% of adults worldwide. Several epidemiological studies indicate that high blood pressure originates in fetal life-the so-called programming effect or developmental origin of hypertension. Iron-deficiency anemia has become one of the most prevalent nutritional problems globally. Previous animal experiments have shown that prenatal iron-deficiency anemia adversely affects offspring hypertension. However, the underlying mechanism remains unclear. We used a maternal low-iron diet Sprague Dawley rat model to study changes in blood pressure, the renal renin-angiotensin system, oxidative stress, inflammation, and sodium transporters in adult male offspring. Our study revealed that 16-week-old male offspring born to mothers with low dietary iron throughout pregnancy and the lactation period had (1) higher blood pressure, (2) increased renal cortex angiotensin II receptor type 1 and angiotensin-converting enzyme abundance, (3) decreased renal cortex angiotensin II receptor type 2 and MAS abundance, and (4) increased renal 8-hydroxy-2'-deoxyguanosine and interleukin-6 abundance. Improving the iron status of pregnant mothers could influence the development of hypertension in their offspring.
高血压是一个重要的公共卫生挑战，影响着全球多达 30-50%的成年人。几项流行病学研究表明，高血压起源于胎儿期，即所谓的编程效应或高血压的发育起源。缺铁性贫血已成为全球最普遍的营养问题之一。先前的动物实验表明，产前缺铁性贫血会对后代的高血压产生不利影响。然而，其潜在机制尚不清楚。我们使用了一种母体低铁饮食 Sprague Dawley 大鼠模型来研究成年雄性后代的血压、肾脏肾素-血管紧张素系统、氧化应激、炎症和钠转运体的变化。我们的研究表明，在整个怀孕期间和哺乳期饮食中铁含量低的母亲所生的 16 周龄雄性后代具有以下特征：（1）血压升高；（2）肾脏皮质血管紧张素 II 受体 1 和血管紧张素转换酶含量增加；（3）肾脏皮质血管紧张素 II 受体 2 和 MAS 含量减少；（4）肾脏 8-羟基-2'-脱氧鸟苷和白细胞介素-6 含量增加。改善孕妇的铁状况可能会影响其后代高血压的发展。
