Gudkov Sergey V, Burmistrov Dmitriy E, Smirnova Veronika V, Semenova Anastasia A, Lisitsyn Andrey B
Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia.
V.M. Gorbatov Federal Research Center for Food Systems of the Russian Academy of Sciences, 109316 Moscow, Russia.
Nanomaterials (Basel). 2022 Jul 30;12(15):2635. doi: 10.3390/nano12152635.
Bacterial antibiotic resistance is one of the most serious modern biomedical problems that prioritizes the search for new agents to combat bacterial pathogens. It is known that nanoparticles of many metals and metal oxides can have an antibacterial effect. However, the antibacterial efficacy of aluminum oxide nanoparticles has been studied little compared to the well-known antimicrobial properties of nanoparticles of oxides of metals such as zinc, silver, iron, and copper. In this review, we have focused on the experimental studies accumulated to date demonstrating the antibacterial effect of aluminum oxide nanoparticles. The review discusses the main ways of synthesis and modification of these nanoparticles, provides the proposed mechanisms of their antibacterial action against gram-positive and gram-negative bacteria, and also compares the antibacterial efficacy depending on morphological characteristics. We have also partially considered the activity of aluminum oxide nanoparticles against water microalgae and fungi. In general, a more detailed study of the antibacterial properties of aluminum oxide nanoparticles is of great interest due to their low toxicity to eukaryotic cells.
细菌抗生素耐药性是现代生物医学领域最严重的问题之一，这使得寻找对抗细菌病原体的新药物成为当务之急。众所周知，许多金属和金属氧化物的纳米颗粒具有抗菌作用。然而，与锌、银、铁和铜等金属氧化物纳米颗粒广为人知的抗菌特性相比，氧化铝纳米颗粒的抗菌效果研究较少。在这篇综述中，我们重点关注了迄今为止积累的证明氧化铝纳米颗粒具有抗菌作用的实验研究。该综述讨论了这些纳米颗粒的主要合成和改性方法，提出了它们对革兰氏阳性菌和革兰氏阴性菌的抗菌作用机制，并根据形态特征比较了抗菌效果。我们还部分考虑了氧化铝纳米颗粒对水微藻和真菌的活性。总体而言，由于氧化铝纳米颗粒对真核细胞毒性较低，对其抗菌特性进行更详细的研究具有重要意义。
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