Wang Yaoling, Jiang Gege, Wang Liping, Chen Minfang, Yang Kang, Wen Kai, Lan Yujie, Hou Niuniu, Li Wei
Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
School of Software & Microelectronics, Peking University, Beijing, China.
EClinicalMedicine. 2022 Aug 3;52:101603. doi: 10.1016/j.eclinm.2022.101603. eCollection 2022 Oct.
The relationship between depressive symptoms (DS) and their conversion patterns over time and the new-onset risk of diseases in the middle-aged and elderly population has not been extensively studied.
Based on The China Health and Retirement Longitudinal Study participants in 2013, we established 13 cohorts involving 12 types of chronic diseases and multimorbidity, who were identified by face-to-face questionnaires. We retrospectively assessed their DS during 2011 and 2013 through the 10-item Center for Epidemiological Studies Depression Scale (CES-D), which were classified into never, newly developed, relieved, and persistent DS, and these participants were followed from 2013 to 2018.
CES-D scores were new-onset risk factors for 9 diseases. The new-onset risk of diseases increased with higher CES-D scores. When CES-D scores were higher than approximately 6, the hazard ratios (HRs) of emergent diseases were greater than 1. DS was independent new-onset risk factors for 8 diseases, with HRs (95% CI) ranging from 1.2635 (1.0061-1.5867) to 1.5231 (1.0717-2.165). Persistent DS was an independent risk factor for most diseases but might be an independent protective factor for new-onset cancer (HR, 95% CI: 0.276, 0.106-0.723).
DS is closely associated with new-onset risk of chronic diseases and multimorbidity, and awareness of the risk associated with pre-DS status (6<CES-D<12) should be raised. chronic disease risks were almost lower with newly developed and relieved DS than with persistent DS, suggesting the potential benefits of active management of DS to reduce the risk of emergent diseases in middle-aged and elderly population.
National Natural Science Foundation of China.
抑郁症状（DS）随时间的变化模式及其与中老年人群新发疾病风险之间的关系尚未得到广泛研究。
基于2013年中国健康与养老追踪调查的参与者，我们建立了13个队列，涉及12种慢性病和多病共存情况，通过面对面问卷调查进行识别。我们通过10项流行病学研究中心抑郁量表（CES-D）回顾性评估了他们在2011年至2013年期间的抑郁症状，分为从未有过、新出现、缓解和持续存在的抑郁症状，并对这些参与者从2013年至2018年进行随访。
CES-D评分是9种疾病的新发风险因素。疾病的新发风险随着CES-D评分的升高而增加。当CES-D评分高于约6分时，新发疾病的风险比（HRs）大于1。抑郁症状是8种疾病的独立新发风险因素，HRs（95%置信区间）范围为1.2635（1.0061 - 1.5867）至1.5231（1.0717 - 2.165）。持续存在的抑郁症状是大多数疾病的独立风险因素，但可能是新发癌症的独立保护因素（HR，95%置信区间：0.276，0.106 - 0.723）。
抑郁症状与慢性病和多病共存的新发风险密切相关，应提高对抑郁症状前期状态（6 < CES-D < 12）相关风险的认识。新出现和缓解的抑郁症状相比持续存在的抑郁症状，慢性病风险几乎更低，这表明积极管理抑郁症状对降低中老年人群新发疾病风险具有潜在益处。
中国国家自然科学基金。
