Rothwell N J, Stock M J, Tedstone A E
Mol Cell Endocrinol. 1987 Jun;51(3):253-7. doi: 10.1016/0303-7207(87)90035-9.
Young male rats were treated with vehicle or ciglitazone (150 mg/kg/day, intragastric) for 8 or 14 days. Drug treatment did not affect food intake but reduced body weight and energy gains over 14 days, and significantly depressed energetic efficiency. Energy expenditure and resting oxygen consumption (VO2), when corrected for body size, were elevated in ciglitazone-treated rats, but the difference in VO2 was abolished by treatment of the animals with a beta-adrenergic antagonist (propranolol). The acute thermic response (postprandial rise in VO2) to a fat meal was similar for both groups, but the response to carbohydrate ingestion was greater in ciglitazone-treated rats (18%) than controls (11.5%). The mass of interscapular brown adipose tissue was not affected by drug treatment, but its protein content was increased and its thermogenic activity (mitochondrial purine nucleotide binding) was elevated by 25% after chronic treatment with ciglitazone. These results indicate that ciglitazone enhances thermogenesis via sympathetic activation of brown adipose tissue, probably as a result of improved insulin sensitivity.
将年轻雄性大鼠用赋形剂或吡格列酮（150毫克/千克/天，灌胃）处理8天或14天。药物治疗不影响食物摄入量，但在14天内降低了体重和能量增加，并显著降低了能量效率。校正体型后，吡格列酮处理的大鼠能量消耗和静息耗氧量（VO2）升高，但用β-肾上腺素能拮抗剂（普萘洛尔）处理动物后，VO2的差异消失。两组对脂肪餐的急性热反应（餐后VO2升高）相似，但吡格列酮处理的大鼠对碳水化合物摄入的反应（18%）大于对照组（11.5%）。药物治疗不影响肩胛间棕色脂肪组织的质量，但长期用吡格列酮治疗后，其蛋白质含量增加，产热活性（线粒体嘌呤核苷酸结合）提高了25%。这些结果表明，吡格列酮可能通过改善胰岛素敏感性，经交感神经激活棕色脂肪组织来增强产热。
