Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
CSIRO Land and Water, 41 Boggo Road, Dutton Park, Queensland, Australia.
Philos Trans A Math Phys Eng Sci. 2022 Oct 3;380(2233):20210314. doi: 10.1098/rsta.2021.0314. Epub 2022 Aug 15.
Mathematical modelling is used during disease outbreaks to compare control interventions. Using multiple models, the best method to combine model recommendations is unclear. Existing methods weight model projections, then rank control interventions using the combined projections, presuming model outputs are directly comparable. However, the way each model represents the epidemiological system will vary. We apply electoral vote-processing rules to combine model-generated rankings of interventions. Combining rankings of interventions, instead of combining model projections, avoids assuming that projections are comparable as all comparisons of projections are made within each model. We investigate four rules: First-past-the-post, Alternative Vote (AV), Coombs Method and Borda Count. We investigate rule sensitivity by including models that favour only one action or including those that rank interventions randomly. We investigate two case studies: the 2014 Ebola outbreak in West Africa (37 compartmental models) and a hypothetical foot-and-mouth disease outbreak in UK (four individual-based models). The Coombs Method was least susceptible to adding models that favoured a single action, Borda Count and AV were most susceptible to adding models that ranked interventions randomly. Each rule chose the same intervention as when ranking interventions by mean projections, suggesting that combining rankings provides similar recommendations with fewer assumptions about model comparability. This article is part of the theme issue 'Technical challenges of modelling real-life epidemics and examples of overcoming these'.
数学建模在疾病爆发期间用于比较控制干预措施。使用多个模型,不清楚如何最好地结合模型建议。现有的方法对模型预测进行加权,然后使用组合预测对控制干预措施进行排名,假设模型输出是直接可比的。然而,每个模型表示流行病学系统的方式将有所不同。我们应用选举投票处理规则来组合模型生成的干预措施排名。通过对干预措施进行排名组合,而不是对模型预测进行组合,可以避免假设预测是可比的,因为所有预测的比较都是在每个模型内进行的。我们研究了四种规则:先过即胜、替代投票、库姆斯法和博尔达计数。我们通过纳入只支持一种行动的模型或纳入随机对干预措施进行排名的模型来研究规则的敏感性。我们研究了两个案例研究:2014 年西非埃博拉疫情(37 个房室模型)和英国假设的口蹄疫疫情(4 个基于个体的模型)。库姆斯法对纳入支持单一行动的模型的敏感性最低,博尔达计数和替代投票对纳入随机对干预措施进行排名的模型的敏感性最高。每个规则选择的干预措施与按平均预测对干预措施进行排名时相同,这表明通过对排名进行组合可以提供类似的建议,而对模型可比性的假设较少。本文是主题为“建模现实疫情的技术挑战及克服这些挑战的实例”的一部分。