Upadhyay Vivek, Bhandari Samrat Singh, Rai Durga Prasad, Dutta Sanjiba, García-Grau Pau, Vaddiparti Krishna
Department of Psychiatry, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Sikkim 737102, India.
Department of Cardiology, Sir Thutob Namgyal Memorial Multispecialty Hospital, Sikkim 737102, India.
Egypt J Neurol Psychiatr Neurosurg. 2022;58. doi: 10.1186/s41983-022-00521-6. Epub 2022 Jul 14.
Depression and low perceived social support (PSS) have been found to deleteriously affect quality of life (QoL) among myocardial infarction (MI) survivors. The complex relationship between these variables has not been assessed. We wanted to assess first the prevalence of depression among MI survivors and whether depression mediates the effect of PSS on QoL and, second, whether the physical and social domains of QoL mediated the effect of depression and PSS on the emotional domain. This cross-sectional study was done among MI survivors using Cardiac Depression Scale, MacNew Quality of Life After Myocardial Infarction Questionnaire and Multidimensional Scale of Perceived Social Support to assess for depression, QoL and PSS respectively.
A total of 103 MI survivors were included in the study, and the mean age was 59.66 (± 10.42) years. Depression was found in 21.36% of the participants. The indirect effect of PSS on QoL with depression as a mediator was significant ( = 0.15, < 0.001, 95% CI 0.12, 0.18). The direct effect of PSS on QoL controlling for depression was also significant ( = 0.05, < 0.001, 95% CI = 0.02, 0.07). Depression as a mediator in the relationship explained 75.3% of the effect of PSS on QoL. PSS and depression did not have a significant direct effect on emotional QoL, but it became significant when the physical and social domains were included in the model. The total indirect effects of PSS and depression on emotional QoL were = 0.16, < 0.001, 95% CI = 0.05, 0.17 and = - 0.05, < 0.001, 95% CI = 0.06, - 0.03, respectively.
Depression and poor PSS impair physical and social domains, which impairs the emotional domain of QoL; as such, overall QoL is undermined. As limited physical and social activity because of depression and poor PSS may increase the risk of further cardiovascular events, a holistic approach which includes mental health care is warranted.
研究发现,抑郁症和低感知社会支持(PSS)会对心肌梗死(MI)幸存者的生活质量(QoL)产生有害影响。这些变量之间的复杂关系尚未得到评估。我们首先想评估MI幸存者中抑郁症的患病率,以及抑郁症是否介导了PSS对QoL的影响;其次,想评估QoL的身体和社会领域是否介导了抑郁症和PSS对情感领域的影响。这项横断面研究在MI幸存者中进行,分别使用心脏抑郁量表、心肌梗死后MacNew生活质量问卷和多维感知社会支持量表来评估抑郁症、QoL和PSS。
共有103名MI幸存者纳入研究,平均年龄为59.66(±10.42)岁。21.36%的参与者存在抑郁症。以抑郁症为中介,PSS对QoL的间接效应显著(=0.15,<0.001,95%CI 0.12,0.18)。控制抑郁症后,PSS对QoL的直接效应也显著(=0.05,<0.001,95%CI=0.02,0.07)。抑郁症作为这种关系中的中介,解释了PSS对QoL效应的75.3%。PSS和抑郁症对情感QoL没有显著直接效应,但当模型中纳入身体和社会领域时,这种效应变得显著。PSS和抑郁症对情感QoL的总间接效应分别为=0.16,<0.001,95%CI=0.05,0.17和=-0.05,<0.001,95%CI=0.06,-0.03。
抑郁症和不良的PSS会损害身体和社会领域,进而损害QoL的情感领域;因此,整体QoL会受到影响。由于抑郁症和不良的PSS导致身体和社会活动受限,可能会增加进一步发生心血管事件的风险,因此需要一种包括心理保健在内的整体方法。