Zhou Lin, Akbar Subiy, Wang Meng-Xi, Chen He-Ping, Liu Ji-Kai
School of Pharmaceutical Sciences, South-Central Minzu University, 430074, Wuhan, China.
Nat Prod Bioprospect. 2022 Aug 16;12(1):32. doi: 10.1007/s13659-022-00356-x.
Chemical investigation on the medicinal fungus Ganoderma australe led to the identification of ten new nor-lanostane triterpenes, namely two hexa-nor ones, ganoaustratetraenones A (1) and B (2), five penta-nor ones, ganoaustraldehydes A-E (3-7), and three tetra-nor ones ganoaustrenoic acids A-C (8-10). The chemical structures along with the absolute configurations were determined by extensive spectroscopic analysis of 1D & 2D NMR and HRESIMS data. The postulated biosynthesis pathways of these compounds were proposed. Ganoaustraldehydes A (3) and B (4) showed moderate inhibition against nitric oxide production in RAW264.7 macrophage cells with the respective IC values of 32.5, 34.2 µM (the IC of positive control pyrrolidine dithiocarbamate was 20.0 µM).
对药用真菌南方灵芝进行化学研究，鉴定出10种新的降羊毛甾烷三萜，即两种六降羊毛甾烷型，南方灵芝四烯酮A（1）和B（2）；五种五降羊毛甾烷型，南方灵芝醛A - E（3 - 7）；以及三种四降羊毛甾烷型，南方灵芝烯酸A - C（8 - 10）。通过对一维和二维核磁共振及高分辨电喷雾电离质谱数据进行广泛的光谱分析，确定了这些化合物的化学结构及其绝对构型。提出了这些化合物的假定生物合成途径。南方灵芝醛A（3）和B（4）对RAW264.7巨噬细胞中一氧化氮的产生表现出中等程度的抑制作用，其IC值分别为32.5、34.2 μM（阳性对照吡咯烷二硫代氨基甲酸盐的IC值为20.0 μM）。
