老年患者急性疾病所致认知功能障碍——一种未被识别的综合征。
Acute disease induced cognitive dysfunction in older patients - an unrecognized syndrome.
机构信息
Department of Geriatric Medicine, Marien Hospital Herne, Ruhr University Bochum, Hölkeskampring 40, D- 44625, Herne, Germany.
出版信息
BMC Geriatr. 2022 Aug 15;22(1):670. doi: 10.1186/s12877-022-03323-w.
BACKGROUND
It is unknown, how many older hospitalized patients experience cognitive changes independently from delirium.
METHODS
In this retrospective study, cognitive function was assessed with the Montreal Cognitive Assessment on admission and discharge in 103 acute care geriatric hospital patients.
RESULTS
Mean age was 80.8 ± 7.3 years. The total MoCA score on admission was 17.8 (±4.5) and at discharge 17.7 (±4.4). The mean difference of the total MoCA score was - 0.1 (±3.5). 12 (11.7%) patients suffered from delirium. 46 (44.7%) patients experienced significant changes of cognitive function <- 2 or > 2 MoCA points without delirium. There was no significant association between delirium during hospital stay and the prevalence and magnitude of changes in total MoCA score.
CONCLUSION
Cognitive changes frequently occur during acute disease of geriatric patients independently from delirium. We propose the term "acute disease induced cognitive dysfunction" (ADICD) for this entity.
TRIAL REGISTRATION
German Clinical trial register (DRKS-ID: DRKS00025157 on 28.04.2021).
背景
目前尚不清楚有多少老年住院患者的认知功能改变是独立于谵妄之外的。
方法
在这项回顾性研究中，我们对 103 例急性老年重症监护病房患者的认知功能进行了评估，使用蒙特利尔认知评估量表在入院时和出院时进行评估。
结果
患者的平均年龄为 80.8±7.3 岁。入院时的总 MoCA 评分为 17.8（±4.5），出院时为 17.7（±4.4）。总 MoCA 评分的平均差值为-0.1（±3.5）。12 例（11.7%）患者发生谵妄。46 例（44.7%）患者在无谵妄的情况下出现认知功能显著变化<-2 或>2 MoCA 分。谵妄与总 MoCA 评分的变化发生率和幅度之间无显著相关性。
结论
老年患者急性疾病期间经常发生认知改变，独立于谵妄之外。我们提出“急性疾病引起的认知功能障碍”（ADICD）这一术语来描述这一现象。
试验注册
德国临床试验注册处（DRKS-ID：DRKS00025157，于 2021 年 4 月 28 日注册）。
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