State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
Oral Dis. 2024 Mar;30(2):528-536. doi: 10.1111/odi.14323. Epub 2022 Aug 16.
Oral lichen planus, a chronic inflammatory immune disease, occurs in the oral mucosa. We aimed to assess the prevalence and possible influencing factors of oral lichen planus in patients with diabetes mellitus.
This cross-sectional study involved 525 patients with diabetes mellitus and 525 controls. We collected information on blood glucose level, duration of diabetes, diabetic complications, treatment methods, other systemic diseases and medication history.
Oral lichen planus was significantly more prevalent in the diabetes mellitus/type 2 diabetes mellitus group than in the controls (2.3%/2.2% vs. 0.6%, p = 0.019/0.022). There was no significant association between patients with diabetes mellitus with and those without oral lichen planus in age (p = 0.195), sex (p = 0.390), blood glucose level (p = 1), duration of diabetes (p = 0.638), diabetic complications (p = 1), treatment methods (p = 0.962), other systemic diseases (p = 0.891) and medication history (p = 0.848).
Diabetes mellitus was associated with oral lichen planus; there was a higher prevalence of oral lichen planus in patients with diabetes mellitus/type 2 diabetes mellitus than in those without diabetes. Oral lichen planus development in patients with diabetes mellitus was not significantly associated with age, sex, blood glucose level, duration of diabetes, diabetic complications, treatment methods, other systemic diseases and medication history.
口腔扁平苔藓是一种慢性炎症性免疫性疾病，发生于口腔黏膜。本研究旨在评估糖尿病患者口腔扁平苔藓的患病率及可能的影响因素。
本横断面研究纳入了 525 例糖尿病患者和 525 名对照者。我们收集了血糖水平、糖尿病病程、糖尿病并发症、治疗方法、其他系统性疾病和用药史等信息。
糖尿病/2 型糖尿病组口腔扁平苔藓的患病率显著高于对照组（2.3%/2.2%比 0.6%，p=0.019/0.022）。有口腔扁平苔藓和无口腔扁平苔藓的糖尿病患者在年龄（p=0.195）、性别（p=0.390）、血糖水平（p=1）、糖尿病病程（p=0.638）、糖尿病并发症（p=1）、治疗方法（p=0.962）、其他系统性疾病（p=0.891）和用药史（p=0.848）方面均无显著差异。
糖尿病与口腔扁平苔藓相关；糖尿病患者口腔扁平苔藓的患病率高于非糖尿病患者。糖尿病患者口腔扁平苔藓的发生与年龄、性别、血糖水平、糖尿病病程、糖尿病并发症、治疗方法、其他系统性疾病和用药史无显著相关性。
