Jiang Chenyu, Shao Yaojian
Department of Geriatric, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.
Department of Gastroenterology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.
Front Nutr. 2024 May 7;11:1392960. doi: 10.3389/fnut.2024.1392960. eCollection 2024.
The dietary inflammatory index (DII) and composite dietary antioxidant index (CDAI) were developed as tools for use when seeking to assess the potential inflammatory and antioxidant activity of a given diet, respectively. The associations between these indices and gallstone incidence remain largely unexplored.
The present study sought to clarify how both the DII and the CDAI are related to gallstone incidence and age at first gallbladder surgery among adults in the USA.
Cross-sectional data from the 2017-2020 cycles of the National Health and Nutrition Examination Survey (NHANES) pertaining to 12,426 individuals were used to conduct the present study. Data from 2 days with 24-h dietary recall were employed when calculating DII and CDAI scores. Relationships between dietary indices and the incidence of gallstones were assessed through logistic regression analyses, while linear regression analyses were employed to characterize how these indices are associated with the age at first gallbladder surgery.
Higher DII scores and lower CDAI scores, which, respectively, denote diets with greater inflammatory potential and reduced antioxidant potential, were found to be associated with higher gallstone incidence even following adjustment for potential confounding factors. Smooth curve fitting suggested that the association between DII and gallstones was nearly linear, whereas that between CDAI and gallstone incidence was nonlinear. Higher DII values were also related to first gallbladder surgery at an earlier age ( = -0.64, 95% CI: -1.26, -0.02).
These results emphasize the benefits of anti-inflammatory diets rich in antioxidants, which may help reduce gallstone incidence among adults in the USA. Higher DII scores may also predict the need for gallbladder surgery at a younger age.
饮食炎症指数（DII）和复合饮食抗氧化指数（CDAI）分别作为评估特定饮食潜在炎症和抗氧化活性的工具而开发。这些指数与胆结石发病率之间的关联在很大程度上仍未得到探索。
本研究旨在阐明DII和CDAI与美国成年人胆结石发病率以及首次胆囊手术年龄之间的关系。
使用来自2017 - 2020年国家健康与营养检查调查（NHANES）的12426名个体的横断面数据进行本研究。在计算DII和CDAI分数时，采用了来自2天24小时饮食回忆的数据。通过逻辑回归分析评估饮食指数与胆结石发病率之间的关系，同时采用线性回归分析来描述这些指数与首次胆囊手术年龄之间的关联。
较高的DII分数和较低的CDAI分数，分别表示具有更大炎症潜力和降低抗氧化潜力的饮食，即使在对潜在混杂因素进行调整后，也被发现与较高的胆结石发病率相关。平滑曲线拟合表明，DII与胆结石之间的关联几乎是线性的，而CDAI与胆结石发病率之间的关联是非线性的。较高的DII值也与较早的首次胆囊手术年龄相关（β = -0.64，95%CI：-1.26，-0.02）。
这些结果强调了富含抗氧化剂的抗炎饮食的益处，这可能有助于降低美国成年人的胆结石发病率。较高的DII分数也可能预测年轻时需要进行胆囊手术。
