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对曾健康个体接种SARS-CoV-2疫苗(新冠病毒免疫接种)后心肌炎的综合分析

A Comprehensive Analysis of Myocarditis in Formerly Healthy Individuals Following SARS-CoV-2 Vaccination (COVID-19 Immunization).

作者信息

Sharma Kamal, Patel Smeet, Patel Zeel, Patel Kalpen B, Doshi Jinish S, Shah Darshini B, Chokshi Priyank, Parbatani Ansh, Sharma Chandan, Patel Akanksha, Konat Ashwati

机构信息

Cardiology, Shah Alloys Limited (SAL) Hospital, Ahmedabad, IND.

Graduate Medical Education, Smt. Nathiba Hargovandas Lakhmichand (NHL) Municipal Medical College, Ahmedabad, IND.

出版信息

Cureus. 2022 Jul 14;14(7):e26851. doi: 10.7759/cureus.26851. eCollection 2022 Jul.

Abstract

Due to the rapid development of the coronavirus disease 2019 (COVID-19) pandemic, the Food and Drug Administration (FDA) expedited the authorization of immunizations to counteract life-threatening COVID-19 effects. COVID-19 immunization was seen as an essential component of surviving endemically with COVID-19. Although there were no major adverse event reports that mandated an early authorization of the mass vaccination approval in initial studies, a few significant adverse events were reported after real-world usage. The most prevalent adverse events are regional reactions, such as discomfort at the injection site. Anaphylactic shock and acute responses were quite infrequent. Current evidence strongly convince the community that the advantages of immunization outweigh the risks. The review investigates the potential adverse reaction in the form of myocarditis caused by the COVID-19 vaccine. Age, sexuality, vaccination type, clinical manifestations, and diagnostic modalities were among the confounding factors associated with vaccine-induced myocarditis. This picture depicts COVID-19 immunization-induced myocarditis and the treatment options available to practitioners. Further evaluation is needed to establish the underlying cause of this association. We compiled the most recent data on SARS-CoV-2 vaccine-induced myocarditis after reviewing available research. Information sources including PubMed and Google Scholar were evaluated retrospectively.

摘要

由于2019冠状病毒病(COVID-19)大流行的迅速发展,美国食品药品监督管理局(FDA)加快了免疫接种的授权,以对抗危及生命的COVID-19影响。COVID-19免疫接种被视为在COVID-19地方流行情况下生存的重要组成部分。尽管在初步研究中没有重大不良事件报告要求提前批准大规模疫苗接种,但在实际使用后报告了一些重大不良事件。最常见的不良事件是局部反应,如注射部位不适。过敏性休克和急性反应相当罕见。目前的证据有力地使社区相信免疫接种的益处大于风险。本综述调查了COVID-19疫苗引起的心肌炎形式的潜在不良反应。年龄、性别、疫苗接种类型、临床表现和诊断方式是与疫苗诱导的心肌炎相关的混杂因素。此图描绘了COVID-19免疫接种引起的心肌炎以及从业者可用的治疗选择。需要进一步评估以确定这种关联的根本原因。在回顾现有研究后,我们汇总了关于严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疫苗诱导心肌炎的最新数据。包括PubMed和谷歌学术在内的信息来源进行了回顾性评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a23/9375127/7b011a5bd835/cureus-0014-00000026851-i01.jpg

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