Xiang Li, Wang Yuru, Xia Fan, Liu Fang, He Daliang, Long Guanhua, Zeng Xiangwen, Liang Xuelei, Jin Chuanhong, Wang Yuwei, Pan Anlian, Peng Lian-Mao, Hu Youfan
Key Laboratory for the Physics and Chemistry of Nanodevices, School of Electronics and Center for Carbon-Based Electronics, Peking University, Beijing 100871, China.
College of Materials Science and Engineering, Hunan University, Changsha 410082, China.
Sci Adv. 2022 Aug 19;8(33):eabp8075. doi: 10.1126/sciadv.abp8075. Epub 2022 Aug 17.
Epidermal electronic systems that simultaneously provide physiological information acquisition, processing, and storage are in high demand for health care/clinical applications. However, these system-level demonstrations using flexible devices are still challenging because of obstacles in device performance, functional module construction, or integration scale. Here, on the basis of carbon nanotubes, we present an epidermal system that incorporates flexible sensors, sensor interface circuits, and an integrated flash memory array to collect physiological information from the human body surface; amplify weak biosignals by high-performance differential amplifiers (voltage gain of 27 decibels, common-mode rejection ratio of >43 decibels, and gain bandwidth product of >22 kilohertz); and store the processed information in the memory array with performance on par with industrial standards (retention time of 10 seconds, program/erase voltages of ±2 volts, and endurance of 10 cycles). The results shed light on the great application potential of epidermal electronic systems in personalized diagnostic and physiological monitoring.
同时具备生理信息采集、处理和存储功能的表皮电子系统在医疗保健/临床应用中需求极高。然而，由于设备性能、功能模块构建或集成规模方面的障碍，这些使用柔性器件的系统级演示仍具有挑战性。在此，基于碳纳米管，我们展示了一种表皮系统，该系统集成了柔性传感器、传感器接口电路和集成闪存阵列，用于从人体表面收集生理信息；通过高性能差分放大器（电压增益为27分贝、共模抑制比>43分贝、增益带宽积>22千赫兹）放大微弱的生物信号；并将处理后的信息存储在与工业标准相当的性能的内存阵列中（保留时间为10秒、编程/擦除电压为±2伏、耐久性为10个循环）。这些结果揭示了表皮电子系统在个性化诊断和生理监测中的巨大应用潜力。
