Circulation. 2022 Sep 20;146(12):e173-e184. doi: 10.1161/CIR.0000000000001089. Epub 2022 Aug 18.
Symptoms of cardiovascular disease drive health care use and are a major contributor to quality of life. Symptoms are of fundamental significance not only to the diagnosis of cardiovascular disease and appraisal of response to medical therapy but also directly to patients' daily lives. The primary purpose of this scientific statement is to present the state of the science and relevance of symptoms associated with cardiovascular disease. Symptoms as patient-reported outcomes are reviewed in terms of the genesis, manifestation, and similarities or differences between diagnoses. Specifically, symptoms associated with acute coronary syndrome, heart failure, valvular disorders, stroke, rhythm disorders, and peripheral vascular disease are reviewed. Secondary aims include (1) describing symptom measurement methods in research and application in clinical practice and (2) describing the importance of cardiovascular disease symptoms in terms of clinical events and other patient-reported outcomes as applicable.
心血管疾病的症状会导致医疗保健的使用，并对生活质量有重大影响。这些症状不仅对心血管疾病的诊断和评估药物治疗反应具有根本意义，而且直接影响到患者的日常生活。本科学声明的主要目的是阐述与心血管疾病相关症状的科学现状和相关性。从病因、表现以及不同诊断之间的相似性或差异性的角度，对作为患者报告结局的症状进行了回顾。具体而言，回顾了与急性冠状动脉综合征、心力衰竭、瓣膜疾病、中风、节律障碍和外周血管疾病相关的症状。次要目标包括：(1) 描述症状测量方法在研究和临床实践中的应用；(2) 描述心血管疾病症状在临床事件和其他患者报告结局方面的重要性。
