Spychala Kellyn M, Yeung Ellen W, Miller Alex P, Slutske Wendy S, Wilhelmsen Kirk C, Gizer Ian R
Department of Psychological Sciences, University of Missouri.
Department of Family Medicine and Community Health, Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health.
Psychol Addict Behav. 2025 Feb;39(1):63-75. doi: 10.1037/adb0001015. Epub 2024 Jun 6.
A propensity for aggression or alcohol use may be associated with alcohol-related aggression. Previous research has shown genetic overlap between alcohol use and aggression but has not looked at how alcohol-related aggression may be uniquely influenced by genetic risk for aggression or alcohol use. The present study examined the associations of genetic risk for trait aggression, alcohol use, and alcohol use disorder (AUD) with alcohol-related aggression using a polygenic risk score (PRS) approach.
Using genome-wide association study summary statistics, PRSs were created for trait aggression, alcohol consumption, and AUD. These PRSs were used to predict the phenotype of alcohol-related aggression among drinkers in two independent samples: the University of California at San Francisco (UCSF) Family Alcoholism Study ( = 1,162) and the National Longitudinal Study of Adolescent to Adult Health (Add Health; = 4,291).
There were significant associations between the AUD PRS and lifetime alcohol-related aggression in the UCSF study sample. Additionally, the trait aggression PRS was associated with three or more experiences of hitting anyone else and getting into physical fights while under the influence of alcohol, along with a composite score of three or more experiences of alcohol-related aggression, in the UCSF study sample. No significant associations were observed in the Add Health sample. Limited sex-specific genetic effects were observed.
These results provide preliminary evidence that genetic influences underlying alcohol use and aggression are uniquely associated with alcohol-related aggression and suggest that these associations may differ by type and frequency of alcohol-related aggression incidents. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
攻击倾向或饮酒行为可能与酒精相关攻击行为有关。先前的研究表明饮酒与攻击行为之间存在基因重叠，但尚未探讨酒精相关攻击行为如何受到攻击倾向或饮酒行为的遗传风险的独特影响。本研究使用多基因风险评分（PRS）方法，检验了特质攻击、饮酒和酒精使用障碍（AUD）的遗传风险与酒精相关攻击行为之间的关联。
利用全基因组关联研究的汇总统计数据，创建了特质攻击、酒精消费和AUD的PRS。这些PRS被用于预测两个独立样本中饮酒者的酒精相关攻击行为表型：加利福尼亚大学旧金山分校（UCSF）家庭酗酒研究（n = 1162）和青少年到成人健康全国纵向研究（Add Health；n = 4291）。
在UCSF研究样本中，AUD的PRS与终生酒精相关攻击行为之间存在显著关联。此外，在UCSF研究样本中，特质攻击的PRS与在酒精影响下殴打他人及发生肢体冲突三次或更多次的经历，以及酒精相关攻击行为三次或更多次经历的综合评分相关。在Add Health样本中未观察到显著关联。观察到有限的性别特异性遗传效应。
这些结果提供了初步证据，表明饮酒和攻击行为背后的遗传影响与酒精相关攻击行为存在独特关联，并表明这些关联可能因酒精相关攻击事件的类型和频率而异。（PsycInfo数据库记录（c）2025美国心理学会，保留所有权利）
