Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil.
Feinberg School of Medicine, Northwestern University, Ann and Robert Lurie Children's Hospital, 420 E Superior St, Chicago, IL, 60611, USA.
Clin Oral Investig. 2022 Dec;26(12):7243-7252. doi: 10.1007/s00784-022-04684-7. Epub 2022 Aug 19.
This in vitro study evaluated the efficacy of toothpaste containing fluoride (F), sodium trimetaphosphate (TMP), and xylitol and erythritol (XE) to inhibit or repair initial enamel erosion lesions.
Bovine enamel blocks (n = 120) were selected according to surface hardness (SH) and randomly divided into 5 experimental groups (n = 24 blocks/group): Placebo (no F, TMP, XE); 1100 ppm F; 16% xylitol + 4% erythritol (XE); 200 ppm F + 0.2% TMP (200 ppm F/TMP); and 200 ppm F + 0.2% TMP + 16% xylitol + 4% erythritol (200 ppm F/TMP/XE). The sound and softened blocks were immersed in toothpaste slurry in human saliva for 2 min. The blocks were then submitted to 4 erosive challenges in citric acid (0.75%, pH 3.5), each challenge for 1 min, with stirring. The SH of the blocks was determined after treatment (t) and after the 4 erosive challenges. In addition, the precipitates were analyzed by scanning electron microscopy (SEM). Variables were submitted to a two-way repeated-measures analysis of variance followed by a Student-Newman-Keuls test (p < 0.05).
Toothpaste containing 200 ppm F/TMP/XE led to the highest protective and repair effect compared to the other groups (p < 0.001). The protective and repair effect was XE > 200 ppm F/TMP > 1100 ppm F > placebo (p < 0.001). All groups produced precipitates with a thicker layer for XE and TMP groups.
Toothpaste containing 200 ppm F, TMP, and polyols demonstrated a superior protective and repair effect in initial enamel erosive lesions in vitro.
Toothpaste containing F and polyols could be an advantage in patients affected by dental erosion, due to its higher preventive potential, mainly in individuals who frequently drink acidic beverages. However, future studies are needed to confirm these results.
本体外研究评估了含氟（F）、三聚磷酸钠（TMP）和木糖醇与赤藓糖醇（XE）的牙膏抑制或修复初始釉质侵蚀病变的功效。
根据表面硬度（SH）选择牛牙釉质块（n=120），并将其随机分为 5 个实验组（n=24 个牙釉质块/组）：安慰剂（不含 F、TMP、XE）；1100ppm F；16%木糖醇+4%赤藓糖醇（XE）；200ppm F+0.2%TMP（200ppm F/TMP）；200ppm F+0.2%TMP+16%木糖醇+4%赤藓糖醇（200ppm F/TMP/XE）。将完好和软化的牙釉质块在人唾液中的牙膏浆中浸泡 2 分钟。然后，将块在柠檬酸（0.75%，pH 值 3.5）中进行 4 次侵蚀挑战，每次 1 分钟，同时搅拌。处理后（t）和 4 次侵蚀挑战后测定牙釉质块的 SH。此外，通过扫描电子显微镜（SEM）分析沉淀物。将变量进行双因素重复测量方差分析，然后进行 Student-Newman-Keuls 检验（p<0.05）。
与其他组相比，含 200ppm F/TMP/XE 的牙膏具有最高的保护和修复效果（p<0.001）。保护和修复效果为 XE>200ppm F/TMP>1100ppm F>安慰剂（p<0.001）。所有组的 XE 和 TMP 组都产生了更厚的沉淀物层。
含 200ppm F、TMP 和多元醇的牙膏在体外具有优异的初始釉质侵蚀病变的保护和修复作用。
含氟和多元醇的牙膏可能对患有牙酸蚀症的患者有益，因为其具有更高的预防潜力，主要适用于经常饮用酸性饮料的个体。然而，需要进一步的研究来证实这些结果。
