Faculty of Mathematics, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Department of Medicine, Western University, London, ON N6A 5C1, Canada.
Comput Biol Med. 2022 Sep;148:105953. doi: 10.1016/j.compbiomed.2022.105953. Epub 2022 Aug 9.
Pneumothorax is a potentially life-threatening condition that can be rapidly and accurately assessed via the lung sliding artefact generated using lung ultrasound (LUS). Access to LUS is challenged by user dependence and shortage of training. Image classification using deep learning methods can automate interpretation in LUS and has not been thoroughly studied for lung sliding. Using a labelled LUS dataset from 2 academic hospitals, clinical B-mode (also known as brightness or two-dimensional mode) videos featuring both presence and absence of lung sliding were transformed into motion (M) mode images. These images were subsequently used to train a deep neural network binary classifier that was evaluated using a holdout set comprising 15% of the total data. Grad-CAM explanations were examined. Our binary classifier using the EfficientNetB0 architecture was trained using 2535 LUS clips from 614 patients. When evaluated on a test set of data uninvolved in training (540 clips from 124 patients), the model performed with a sensitivity of 93.5%, specificity of 87.3% and an area under the receiver operating characteristic curve (AUC) of 0.973. Grad-CAM explanations confirmed the model's focus on relevant regions on M-mode images. Our solution accurately distinguishes between the presence and absence of lung sliding artefacts on LUS.
气胸是一种潜在的危及生命的病症,可以通过肺部超声(LUS)产生的肺滑动伪影快速准确地评估。LUS 的使用受到用户依赖性和培训短缺的限制。使用深度学习方法进行图像分类可以实现 LUS 的自动解释,而对于肺滑动,这种方法尚未得到深入研究。使用来自 2 家学术医院的标注 LUS 数据集,对既有也没有肺滑动特征的临床 B 模式(也称为亮度或二维模式)视频进行转换,生成 M 模式图像。随后,这些图像被用于训练一个深度神经网络二分类器,该分类器使用总数据的 15%作为保留数据集进行评估。我们使用 EfficientNetB0 架构的二分类器使用了 614 名患者的 2535 个 LUS 片段进行训练。当在未参与训练的测试数据集(来自 124 名患者的 540 个片段)上进行评估时,该模型的敏感性为 93.5%,特异性为 87.3%,受试者工作特征曲线(ROC)下面积(AUC)为 0.973。Grad-CAM 解释证实了模型对 M 模式图像上相关区域的关注。我们的解决方案可以准确地区分 LUS 上肺滑动伪影的存在和不存在。