Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, 210037 Nanjing, China; Department of Chemical Engineering, Sharif University of Technology, Tehran, Iran.
Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
Carbohydr Polym. 2022 Nov 1;295:119787. doi: 10.1016/j.carbpol.2022.119787. Epub 2022 Jun 27.
Tissue adhesives have been widely used for preventing wound leaks, sever bleeding, as well as for enhancing drug delivery and biosensing. However, only a few among suggested platforms cover the circumstances required for high-adhesion strength and biocompatibility, without toxicity. Antibacterial properties, controllable degradation, encapsulation capacity, detectability by image-guided procedures and affordable price are also centered to on-demand tissue adhesives. Herein we overview the history of tissue adhesives, different types of polysaccharide-based tissue adhesives, their mechanism of gluing, and different applications of polysaccharide-based tissue adhesives. We also highlight the latest progresses in engineering of tissue adhesives followed by existing challenges in fabrication processes. We argue that future studies have to place focus on a holistic understanding of biomaterials and tissue surface properties, proper fabrication procedures, and development of magnetic and conductive responsive adhesives in order to bridge the huge gap between the present studies for clinical implementation.
组织粘合剂已被广泛应用于防止伤口渗漏、控制严重出血，以及增强药物输送和生物传感性能。然而，目前提出的许多平台都无法满足高粘合强度和生物相容性的要求，同时还不能具有毒性。抗菌性能、可控降解性、封装能力、通过图像引导程序的可检测性以及可承受的价格也是按需组织粘合剂的关注重点。本文综述了组织粘合剂的历史、基于多糖的不同类型的组织粘合剂、它们的粘合机制以及基于多糖的组织粘合剂的不同应用。我们还强调了组织粘合剂工程的最新进展以及制造过程中存在的挑战。我们认为，未来的研究必须关注对生物材料和组织表面特性的全面理解、适当的制造工艺以及磁性和导电性响应性粘合剂的开发，以便缩小目前研究与临床应用之间的巨大差距。
