Morales W J
Obstet Gynecol. 1987 Aug;70(2):183-6.
This report investigates the effect of chorioamnionitis on infant mental and psychomotor development at one year through the prospective study of 698 preterm pregnancies complicated by premature rupture of membranes and managed expectantly without antenatal corticosteroids or tocolytic agents. Ninety-two mothers (13%) developed chorioamnionitis, resulting in a statistically significant increase in neonatal mortality (25 versus 6%), respiratory distress syndrome (RDS) (62 versus 35%), intraventricular hemorrhage (56 versus 22%), and sepsis (28 versus 11%). A multidisciplinary team examined 43 surviving infants at corrected one year of life and measured their mental and psychomotor development by the Bayley scales. No statistically significant difference in outcomes was observed when their development was compared with that of a control group matched for birth weight, gestational age, severity of intraventricular hemorrhage, and severity of RDS.
本报告通过对698例合并胎膜早破且未使用产前糖皮质激素或宫缩抑制剂进行期待治疗的早产妊娠进行前瞻性研究，调查绒毛膜羊膜炎对婴儿1岁时智力和精神运动发育的影响。92名母亲（13%）发生绒毛膜羊膜炎，导致新生儿死亡率（25%对6%）、呼吸窘迫综合征（RDS）（62%对35%）、脑室内出血（56%对22%）和败血症（28%对11%）在统计学上显著增加。一个多学科团队在矫正年龄1岁时对43名存活婴儿进行了检查，并通过贝利量表测量了他们的智力和精神运动发育。将他们的发育情况与出生体重、胎龄、脑室内出血严重程度和RDS严重程度相匹配的对照组进行比较时，未观察到结果有统计学上的显著差异。
