Wei Jiao, Hui Ai-Min
Fosun Pharma USA Inc., Boston, MA 02421, USA.
Shanghai Fosun Pharmaceutical Industrial Development, Co., Ltd., Shanghai 200233, China.
Life (Basel). 2022 Aug 17;12(8):1254. doi: 10.3390/life12081254.
mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers. For effective vaccination, mRNA formulation, delivery method and composition of the mRNA carrier play an important role. mRNA vaccines can be delivered using lipid nanoparticles, polymers, peptides or naked mRNA. The vaccine efficacy is influenced by the appropriate delivery materials, formulation methods and selection of a proper administration route. In addition, co-delivery of several mRNAs could also be beneficial and enhance immunity against various variants of an infectious pathogen or several pathogens altogether. Here, we review the recent progress in the delivery methods, modes of delivery and patentable mRNA vaccine technologies.
在过去两年抗击新冠疫情中，信使核糖核酸（mRNA）疫苗具有变革性意义。它们还成为预防传染病和治疗癌症的通用工具。为实现有效接种，mRNA制剂、递送方法以及mRNA载体的组成发挥着重要作用。mRNA疫苗可通过脂质纳米颗粒、聚合物、肽或裸mRNA进行递送。疫苗效力受合适的递送材料、制剂方法以及适当给药途径的选择影响。此外，同时递送多种mRNA也可能有益，可增强针对传染病原体多种变体或多种病原体的免疫力。在此，我们综述了递送方法、递送模式及可获专利的mRNA疫苗技术的最新进展。
