Chemistry of Tanning Materials and Leather Technology Department, National Research Centre, Dokki, Cairo 12622, Egypt.
Nutrition and Food Sciences Department, National Research Centre, Dokki, Cairo 12622, Egypt.
Molecules. 2022 Aug 12;27(16):5159. doi: 10.3390/molecules27165159.
L. is reported for its anti-obese and anti-diabetic activities. The present study aimed to investigate its aqueous methanol leaf extract (CLL) in vivo anti-obese activity along with the isolation and identification of bioactive compounds and their in vitro α-glucosidase inhibition assessment. CLL improved all obesity complications and exhibited significant activity in an obese rat model. Fourteen compounds, including four flavone glycosides (-) and ten dihydrochalcone glycosides (-), were isolated and identified using spectroscopic techniques. New compounds identified in planta included () apigenin 6--(2-deoxy--D-galactopyranoside)-7---D-quinovopyranoside, () phloretin 3'--(2--()-cinnamoyl-3---D-fucopyranosyl-4--acetyl)--D-fucopyranosyl-6'---D fucopyranosyl-(1/2)-α-L arabinofuranoside, () phloretin3'--(2--()-p-coumaroyl-3--D-fucosyl-4--acetyl)--D-fucosyl-6'--(2---D-fucosyl)-α-L-arabinofuranoside, () phloretin3'--(2-O--coumaroyl-3---D-fucosyl-4--acetyl)--D-fucosyl-6'--(2---D-fucosyl)-α-L-arabinofuranoside. Carambolaside M (), carambolaside Ia (), carambolaside J (), carambolaside I (), carambolaside P (), carambolaside O (), and carambolaside Q (), which are reported for the first time from L. leaves, whereas luteolin 6--α-L-rhamnopyranosyl-(1-2)--D-fucopyranoside (), apigenin 6---D-galactopyranoside (), and apigenin 6---L-rhamnopyranosyl-(1-2)--L-fucopyranoside () are isolated for the first time from Family. Oxalidaceae. In vitro α-glucosidase inhibitory activity revealed the potential efficacy of flavone glycosides, viz., , , , and as antidiabetic agents. In contrast, dihydrochalcone glycosides (-) showed weak activity, except for compound , which showed relatively strong activity.
莱菔子（L.）具有抗肥胖和抗糖尿病的作用。本研究旨在探讨其水甲醇叶提取物（CLL）在体内抗肥胖活性，同时分离和鉴定生物活性化合物，并评估其体外α-葡萄糖苷酶抑制活性。CLL 改善了所有肥胖并发症，并在肥胖大鼠模型中表现出显著的活性。使用光谱技术分离和鉴定了 14 种化合物，包括 4 种黄酮糖苷（-）和 10 种二氢查尔酮糖苷（-）。在植物中鉴定出的新化合物包括（）芹菜素 6--（2-去氧--D-吡喃半乳糖苷）-7---D-奎诺吡喃糖苷、（）根皮素 3'--（2--()-肉桂酰基-3---D-岩藻糖苷基-4--乙酰基）-D-岩藻糖苷基-6'---D 岩藻糖苷基（1/2）-α-L-阿拉伯呋喃糖苷、（）根皮素 3'--（2--()-对香豆酰基-3--D-岩藻糖基-4--乙酰基）-D-岩藻糖苷基-6'--（2---D-岩藻糖苷基）-α-L-阿拉伯呋喃糖苷、（）根皮素 3'--（2-O--对香豆酰基-3---D-岩藻糖基-4--乙酰基）-D-岩藻糖苷基-6'--（2---D-岩藻糖苷基）-α-L-阿拉伯呋喃糖苷。首次从莱菔子叶中报道了 carambolaside M（）、carambolaside Ia（）、carambolaside J（）、carambolaside I（）、carambolaside P（）、carambolaside O（）和 carambolaside Q（），而 luteolin 6--α-L-鼠李吡喃糖苷基-（1-2）--D-岩藻糖苷（）、芹菜素 6---D-吡喃半乳糖苷（）和芹菜素 6---L-鼠李吡喃糖苷基-（1-2）--L-吡喃岩藻糖苷（）首次从茄科中分离得到。体外α-葡萄糖苷酶抑制活性显示了黄酮糖苷（即，、、、和）作为抗糖尿病药物的潜在功效。相比之下，二氢查尔酮糖苷（-）表现出较弱的活性，除了化合物外，其表现出相对较强的活性。
