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建立中国川南地区血清维生素 A 和维生素 E 浓度参考范围。

Establishment of Reference Range for Serum Concentration of Vitamin A and Vitamin E in Southern Sichuan Area of China.

机构信息

Zigong Maternity and Child Health Care Hospital, Sichuan Zigong, China.

Sichuan Sanwu Technology Co., Ltd, Sichuan Chengdu, China.

出版信息

J Clin Lab Anal. 2024 May;38(10):e25074. doi: 10.1002/jcla.25074. Epub 2024 Jun 7.

DOI:10.1002/jcla.25074
PMID:38847175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11211669/
Abstract

OBJECTIVE

To establish the reference range of serum concentration of vitamin A (VA) and vitamin E (VE) in Southern Sichuan area of China.

METHODS

From August 1, 2021, to May 31, 2023, 9482 blood tablets were received for the screening of VA and VE. The information was divided into four different age groups: ≤1 year old, 1< to ≤6 years, 6< to ≤17 years, and 17< to ≤59 years. In each age group, the four seasons were further subdivided into spring, summer, autumn, and winter, as well as male and female genders. The serum concentration of VA and VE was detected by liquid chromatography-tandem mass spectrometry (HPLC-MS), and the reference range was established for verification.

RESULTS

The concentration of VA and VE in 9482 cases showed skewed distribution. When comparing between different age groups, the serum concentration of VA and VE was statistically significant (p < 0.05). While comparing different seasons, the serum VA levels in different seasons were significantly different (p < 0.05) except in summer and autumn. There was statistical significance in VE level in different seasons (p < 0.05). And while comparing different genders, there was no statistical significance in VA concentration levels (p > 0.05). The VE concentration levels were statistically significant (p < 0.05). The established reference range was established and verified, and the results were in accordance with the standard.

CONCLUSION

The reference range of VA and VE should be set according to different ages, different seasons, and different genders.

摘要

目的

建立中国川南地区血清维生素 A（VA）和维生素 E（VE）浓度参考范围。

方法

2021 年 8 月 1 日至 2023 年 5 月 31 日，共收到 9482 份血片进行 VA 和 VE 筛查。信息分为四个不同年龄组：≤1 岁、1<至≤6 岁、6<至≤17 岁和 17<至≤59 岁。在每个年龄组中，进一步将四季分为春、夏、秋、冬，以及男女。采用液相色谱-串联质谱法（HPLC-MS）检测 VA 和 VE 血清浓度，并建立参考范围进行验证。

结果

9482 例 VA 和 VE 浓度呈偏态分布。比较不同年龄组时，VA 和 VE 血清浓度有统计学差异（p<0.05）。比较不同季节时，不同季节的血清 VA 水平差异有统计学意义（p<0.05），但夏季和秋季除外。不同季节的 VE 水平差异有统计学意义（p<0.05）。比较不同性别时，VA 浓度水平无统计学差异（p>0.05）。VE 浓度水平有统计学差异（p<0.05）。建立了参考范围并进行了验证，结果符合标准。

结论

VA 和 VE 的参考范围应根据不同年龄、季节和性别进行设定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/86315b46f184/JCLA-38-e25074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/931e3e70d400/JCLA-38-e25074-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/a03f2aae529e/JCLA-38-e25074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/5e58e5df7fed/JCLA-38-e25074-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/4fd1050a2be2/JCLA-38-e25074-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/a44f9e666958/JCLA-38-e25074-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/86315b46f184/JCLA-38-e25074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/931e3e70d400/JCLA-38-e25074-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/a03f2aae529e/JCLA-38-e25074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/5e58e5df7fed/JCLA-38-e25074-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/4fd1050a2be2/JCLA-38-e25074-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/a44f9e666958/JCLA-38-e25074-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df7a/11211669/86315b46f184/JCLA-38-e25074-g002.jpg

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本文引用的文献

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Current Applications of Liposomes for the Delivery of Vitamins: A Systematic Review.脂质体在维生素递送中的当前应用：一项系统评价。
Nanomaterials (Basel). 2023 May 5;13(9):1557. doi: 10.3390/nano13091557.
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Dietary vitamin A intakes of chinese children with adequate liver stores as assessed by the retinol isotope dilution technique.采用视黄醇同位素稀释技术评估中国儿童肝脏储备充足时的膳食维生素 A 摄入量。
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