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装饰有TiO/Ag纳米颗粒的棉湿巾对新冠病毒德尔塔变异株的灭活及杀菌性能,如巴西重果型棉湿巾。

Delta SARS-CoV-2 inactivation and bactericidal performance of cotton wipes decorated with TiO/Ag nanoparticles like Brazilian heavy-fruited .

作者信息

da Silva Daniel J, Duran Adriana, Cabral Aline D, Fonseca Fernando L A, Bueno Rodrigo F, Wang Shu Hui, Rosa Derval S

机构信息

Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Av. dos Estados 5001, Santo André, SP 09210-210, Brazil.

Department of Metallurgical and Materials Engineering, Polytechnic School, University of São Paulo, Av. Prof. Mello Moraes 2643, São Paulo, SP, 05508-030, Brazil.

出版信息

Mater Today Commun. 2022 Dec;33:104288. doi: 10.1016/j.mtcomm.2022.104288. Epub 2022 Aug 22.

Abstract

The current pandemic of Coronavirus Disease 2019 (COVID-19) raised several concerns about using conventional textiles for manufacturing personal protective equipment without self-disinfecting properties since the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is transmitted mainly by aerosols that can transpose cotton masks. Therefore, developing new cotton fibers with high self-disinfecting ability is essential to avoid a new pandemic due to new SARS-CoV-2 variants. Herein, we developed cotton wipes (CFs) with fibers coated by Ag, TiO, and Ag/TiO hybrid nanoparticles like Brazilian heavy-fruited by a sonochemical approach. Moreover, the coated CFs present high antimicrobial performance against () and (), being able to inactivate infectious SARS-CoV-2 (Delta variant) by the destruction of the spike, membrane, and nucleocapsid proteins while the viral RNA is not significantly affected, according to the molecular biological findings.

摘要

2019年冠状病毒病(COVID-19)的当前大流行引发了人们对使用无自我消毒特性的传统纺织品制造个人防护装备的诸多担忧,因为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)主要通过可穿透棉质口罩的气溶胶传播。因此,开发具有高自我消毒能力的新型棉纤维对于避免因新的SARS-CoV-2变种引发新的大流行至关重要。在此,我们通过声化学方法开发了涂覆有银、二氧化钛和银/二氧化钛混合纳米颗粒的棉擦拭布(CFs),类似于巴西重果棉。此外,根据分子生物学研究结果,涂覆的CFs对()和()具有高抗菌性能,能够通过破坏刺突、膜和核衣壳蛋白来灭活传染性SARS-CoV-2(Delta变种),而病毒RNA未受到显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d205/9394096/beb619003f32/ga1_lrg.jpg

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